Effect of lomefloxacin on theophylline pharmacokinetics

D. E. Nix, A. Norman, J. J. Schentag

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Abstract

A study involving 25 healthy male volunteers was conducted to evaluate the effect of lomefloxacin on the pharmacokinetics of theophylline. The mean age was 22.4 ± 3.0 years, and the mean weight was 77.3 ± 7.7 kg. A single 6-mg/kg aminophylline dose was given intravenously on study days 1 and 15. The subjects received a 400-mg lomefloxacin dose (four 100-mg capsules) on study days 9 through 15. No treatment was given on study days 2 through 8. Thirteen blood samples were collected within 24 h after each aminophylline dose. Theophylline concentration in serum were measured by enzyme immunoassay (EMIT). The mean aminophylline dose was 437 ± 36 mg, equivalent to 344 mg of theophylline. Multiple doses of lomefloxacin had no effect on the area under the concentration-time curve from 0 h to infinity, maximal concentration, or clearance of theophylline from serum. There was a slight increase in the theophylline half-life from 6.72 ± 1.63 to 7.02 ± 1.37 h after lomefloxacin dosing (P = 0.04); however, the change was clinically insignificant. No change in theophylline dose is required when lomefloxacin therapy is instituted in a patient receiving theophylline.

Original languageEnglish (US)
Pages (from-to)1006-1008
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume33
Issue number7
DOIs
StatePublished - Jan 1 1989
Externally publishedYes

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ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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