Effect of moderate malnutrition on immediate hypersensitivity and immunoglobulin E levels in asthmatic children

Marco A. Reyes, Nancy G. Saravia, Ronald R Watson, David N. McMurray

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Dermal reactions and IgE levels were compared in 51 asthmatic Colombian children identified on the basis of anthropometric measurements as nutritionally normal (25) or mildly (16) or moderately (10) undernourished. Twenty-five nonatopic children served as controls. Total serum IgE concentrations were significantly elevated in the asthmatic group as a whole. Moderately malnourished (grade 11) asthmatic children had more than twice as much serum IgE as normal or mildly malnourished (grade I) asthmatic subjects and seven times more than nonatopic children. Intestinal parasitism did not appear to contribute to these differences in IgE levels. Serum levels of IgA and IgD were similarly elevated in grade II asthmatics. Concentrations of serum IgG, IgM, and C3 and C4 complement were unaffected by nutritional or allergic status. Eosinophilia in nasal mucus was significantly reduced in grade I and grade II malnourished asthmatic children. Among asthmatics, the most frequent dermal reactions were to mite antigens (96%), house dust (67%), and grass pollens (35%). Significant levels of specific IgE were detected by the RAST to two species of mites in nearly all atopic children. There was no apparent influence of nutritional status on the distribution of reactivity to a particular allergen by either dermal reactivity or specific IgE assay. The clinical significance of hyper immunoglobulin E in atopic, moderately malnourished children remains to be elucidated.

Original languageEnglish (US)
Pages (from-to)94-100
Number of pages7
JournalJournal of Allergy and Clinical Immunology
Volume70
Issue number2
DOIs
StatePublished - 1982
Externally publishedYes

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Immediate Hypersensitivity
Malnutrition
Immunoglobulin E
Serum
Skin
Dermatophagoides Antigens
Complement C4
Immunoglobulin D
Complement C3
Mites
Eosinophilia
Mucus
Pollen
Poaceae
Nutritional Status
Nose
Allergens
Immunoglobulin A
Immunoglobulin M
Immunoglobulin G

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Effect of moderate malnutrition on immediate hypersensitivity and immunoglobulin E levels in asthmatic children. / Reyes, Marco A.; Saravia, Nancy G.; Watson, Ronald R; McMurray, David N.

In: Journal of Allergy and Clinical Immunology, Vol. 70, No. 2, 1982, p. 94-100.

Research output: Contribution to journalArticle

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