Effect of Modest Caloric Restriction on Oxidative Stress in Women, a Randomized Trial

Maciej S. Buchowski, Nobuko Hongu, Sari Acra, Li Wang, Joshua Warolin, L. Jackson Roberts

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Objectives: It is not established to what extent caloric intake must be reduced to lower oxidative stress in humans. The aim of this study was to determine the effect of short-term, moderate caloric restriction on markers of oxidative stress and inflammation in overweight and obese premenopausal women. Materials/Methods: Randomized trial comparison of 25% caloric restriction (CR) or control diet in 40 overweight or obese women (body mass index 32±5.8 kg/m2) observed for 28 days and followed for the next 90 days. Weight, anthropometry, validated markers of oxidative stress (F2-isoprostane) and inflammation (C-reactive protein), adipokines, hormones, lipids, interleukins, and blood pressure were assessed at baseline, during the intervention, and at follow-up. Results: Baseline median F2-isoprostane concentration (57.0, IQR = 40.5-79.5) in the CR group was 1.75-fold above average range for normal weight women (32.5 pg/ml). After starting of the caloric restriction diet, F2-isoprostane levels fell rapidly in the CR group, reaching statistical difference from the control group by day 5 (median 33.5, IQR = 26.0-48.0, P<0.001) and remained suppressed while continuing on the caloric restriction diet. Three months after resuming a habitual diet, concentrations of F2-isoprostane returned to baseline elevated levels in ~80% of the women. Conclusions: Oxidative stress can be rapidly reduced and sustained through a modest reduction in caloric intake suggesting potential health benefits in overweight and obese women. Trial Registration: Clinicaltrials.gov NCT00808275 http://clinicaltrials.gov/ct2/show/NCT00808275.

Original languageEnglish (US)
Article numbere47079
JournalPLoS One
Volume7
Issue number10
DOIs
StatePublished - Oct 5 2012

Fingerprint

Caloric Restriction
Oxidative stress
F2-Isoprostanes
Oxidative Stress
oxidative stress
Nutrition
Diet
diet
Energy Intake
energy intake
inflammation
adipokines
Anthropometry
Inflammation
C-reactive protein
Weights and Measures
interleukins
anthropometric measurements
Adipokines
Interleukins

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Effect of Modest Caloric Restriction on Oxidative Stress in Women, a Randomized Trial. / Buchowski, Maciej S.; Hongu, Nobuko; Acra, Sari; Wang, Li; Warolin, Joshua; Roberts, L. Jackson.

In: PLoS One, Vol. 7, No. 10, e47079, 05.10.2012.

Research output: Contribution to journalArticle

Buchowski, Maciej S. ; Hongu, Nobuko ; Acra, Sari ; Wang, Li ; Warolin, Joshua ; Roberts, L. Jackson. / Effect of Modest Caloric Restriction on Oxidative Stress in Women, a Randomized Trial. In: PLoS One. 2012 ; Vol. 7, No. 10.
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