Effect of mouse epidermal growth factor/urogastrone on the functional maturation of rat intestine

Yuji Oka, Fayez K. Ghishan, Harry L. Greene, David N. Orth

Research output: Contribution to journalArticle

84 Scopus citations

Abstract

Mouse epidermal growth factor/urogastrone (EGF/UG), administered sc in a dose of 0.1 μg/g BW twice daily for 3 days, increased intestinal weight per unit length, lactase specific activity, and net calcium transport in normal 2-weekold suckling rats, but had no effect on maltase or sucrase specific activity. In normal 3-week-old weanling rats, the intestinal function of which is essentially fully mature, EGF/UG had no effect. These results suggest that EGF/UG, either secreted endogenously or ingested in breast milk, may have a role in both the morphological and functional maturation of the suckling rat intestine.

Original languageEnglish (US)
Pages (from-to)940-944
Number of pages5
JournalEndocrinology
Volume112
Issue number3
DOIs
StatePublished - Mar 1983

ASJC Scopus subject areas

  • Endocrinology

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