Effect of number of conceptuses on maternal mammary development during pregnancy in the pig

R. S. Kensinger, Robert J Collier, F. W. Bazer

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

An experiment was conducted to determine if manipulation of conceptus number could alter estrogen, progesterone or prolactin concentrations in gilts and thereby influence mammary development. Estradiol-valerate injections, oviduct ligation or no treatment were utilized to form three groups of gilts with zero (n=5), 4 to 7 (n=4), or 8 to 11 (n=4) conceptuses, respectively. Blood samples were taken throughout pregnancy, and at day 110 of gestation all gilts were slaughtered and total mastectomies were performed. Mammary glands were analyzed for wet weights, dry weights, RNA and DNA contents. Results indicated conceptuses stimulated mammary development since mammary glands from pseudopregnant gilts had only 22% as much DNA as mammae from pregnant gilts. However, mammary DNA was not different between gilts with 4 to 7 or 8 to 11 conceptuses. The relationship between conceptus number and mammary gland DNA in gilts was best described by the quadratic equation y = 577 + 583x - 38x2, where y = total mammary DNA (mg) and x = conceptus number. Significant positive among-animal and within-group correlations between estrogen-sulfate or estrone concentrations in blood and maternal mammary DNA content suggest that estrogens may be the primary conceptus-derived mammogenic hormone in gilts.

Original languageEnglish (US)
Pages (from-to)237-245
Number of pages9
JournalDomestic Animal Endocrinology
Volume3
Issue number4
DOIs
StatePublished - 1986
Externally publishedYes

Fingerprint

mammary development
conceptus
gilts
Breast
Swine
Mothers
pregnancy
Pregnancy
swine
DNA
Human Mammary Glands
Estrogens
estradiol valerate
mammary glands
estrogens
breasts
Simple Mastectomy
Weights and Measures
Animal Mammary Glands
Oviducts

ASJC Scopus subject areas

  • Animal Science and Zoology
  • Endocrinology
  • veterinary(all)

Cite this

Effect of number of conceptuses on maternal mammary development during pregnancy in the pig. / Kensinger, R. S.; Collier, Robert J; Bazer, F. W.

In: Domestic Animal Endocrinology, Vol. 3, No. 4, 1986, p. 237-245.

Research output: Contribution to journalArticle

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