Effect of oral contraceptives on plasma clearance

Dean E. Carter, Rubin Bressler, Mark R. Hughes, Mark R Haussler, C. Donald Christian, M. Wayne Heine

Research output: Contribution to journalArticle

27 Scopus citations


The effects of chronic steroid contraceptive therapy on drug clearance from plasma were studied by using plasma antipyrine, phenylbutazone, and cholecalciferol half-lives in women. After 3 mo of oral steroid therapy (Norinyl, 2 mg; norethindrone + mestranol), the antipyrine half-life was increased in 3 of 6 subjects, phenylbutazone half-life was not consistently altered, and vitamin D3 half-life was increased in 3 of 4 patients. After 1 to 7 yr of oral steroid therapy, the antipyrine half-life was longer while taking the contraceptive than when the contraceptive treatment was discontinued in 4 of 6 subjects, whereas that of phenylbutazone was not consistently altered.

Original languageEnglish (US)
Pages (from-to)700-707
Number of pages8
JournalClinical Pharmacology and Therapeutics
Issue number6
Publication statusPublished - Dec 1975


ASJC Scopus subject areas

  • Pharmacology

Cite this

Carter, D. E., Bressler, R., Hughes, M. R., Haussler, M. R., Christian, C. D., & Heine, M. W. (1975). Effect of oral contraceptives on plasma clearance. Clinical Pharmacology and Therapeutics, 18(6), 700-707.