Effect of oral contraceptives on plasma clearance

Dean E. Carter, Rubin Bressler, Mark R. Hughes, Mark R Haussler, C. Donald Christian, M. Wayne Heine

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

The effects of chronic steroid contraceptive therapy on drug clearance from plasma were studied by using plasma antipyrine, phenylbutazone, and cholecalciferol half-lives in women. After 3 mo of oral steroid therapy (Norinyl, 2 mg; norethindrone + mestranol), the antipyrine half-life was increased in 3 of 6 subjects, phenylbutazone half-life was not consistently altered, and vitamin D3 half-life was increased in 3 of 4 patients. After 1 to 7 yr of oral steroid therapy, the antipyrine half-life was longer while taking the contraceptive than when the contraceptive treatment was discontinued in 4 of 6 subjects, whereas that of phenylbutazone was not consistently altered.

Original languageEnglish (US)
Pages (from-to)700-707
Number of pages8
JournalClinical Pharmacology and Therapeutics
Volume18
Issue number6
StatePublished - Dec 1975

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Oral Contraceptives
Antipyrine
Phenylbutazone
Half-Life
Contraceptive Agents
Cholecalciferol
Steroids
Mestranol
Norethindrone
Therapeutics
Drug Therapy

ASJC Scopus subject areas

  • Pharmacology

Cite this

Carter, D. E., Bressler, R., Hughes, M. R., Haussler, M. R., Christian, C. D., & Heine, M. W. (1975). Effect of oral contraceptives on plasma clearance. Clinical Pharmacology and Therapeutics, 18(6), 700-707.

Effect of oral contraceptives on plasma clearance. / Carter, Dean E.; Bressler, Rubin; Hughes, Mark R.; Haussler, Mark R; Christian, C. Donald; Heine, M. Wayne.

In: Clinical Pharmacology and Therapeutics, Vol. 18, No. 6, 12.1975, p. 700-707.

Research output: Contribution to journalArticle

Carter, DE, Bressler, R, Hughes, MR, Haussler, MR, Christian, CD & Heine, MW 1975, 'Effect of oral contraceptives on plasma clearance', Clinical Pharmacology and Therapeutics, vol. 18, no. 6, pp. 700-707.
Carter DE, Bressler R, Hughes MR, Haussler MR, Christian CD, Heine MW. Effect of oral contraceptives on plasma clearance. Clinical Pharmacology and Therapeutics. 1975 Dec;18(6):700-707.
Carter, Dean E. ; Bressler, Rubin ; Hughes, Mark R. ; Haussler, Mark R ; Christian, C. Donald ; Heine, M. Wayne. / Effect of oral contraceptives on plasma clearance. In: Clinical Pharmacology and Therapeutics. 1975 ; Vol. 18, No. 6. pp. 700-707.
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