Effect of pH on injection phlebitis

P. Simamora, S. Pinsuwan, J. M. Alvarez, Paul B Myrdal, Samuel H Yalkowsky

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Formulation pH has been reported to be responsible for the incidence of phlebitis. In this study, the effect of pH on injection phlebitis is investigated. Buffers of varying pHs were examined for their ability to produce phlebitis in rabbits. Thermal measurements as well as visual evaluations were used for phlebitis quantitation. The results show that formulation pH between 3.0 and 11.0 does not contribute to the incidence of phlebitis when administered as an iv bolus injection.

Original languageEnglish (US)
Pages (from-to)520-522
Number of pages3
JournalJournal of Pharmaceutical Sciences
Volume84
Issue number4
DOIs
StatePublished - 1995

Fingerprint

Phlebitis
Buffers
Injections
Incidence
Hot Temperature
Rabbits

ASJC Scopus subject areas

  • Drug Discovery
  • Organic Chemistry
  • Chemistry(all)
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science

Cite this

Effect of pH on injection phlebitis. / Simamora, P.; Pinsuwan, S.; Alvarez, J. M.; Myrdal, Paul B; Yalkowsky, Samuel H.

In: Journal of Pharmaceutical Sciences, Vol. 84, No. 4, 1995, p. 520-522.

Research output: Contribution to journalArticle

Simamora, P. ; Pinsuwan, S. ; Alvarez, J. M. ; Myrdal, Paul B ; Yalkowsky, Samuel H. / Effect of pH on injection phlebitis. In: Journal of Pharmaceutical Sciences. 1995 ; Vol. 84, No. 4. pp. 520-522.
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