Effect of quinine on digoxin kinetics

M. Wandell, J. R. Powell, W. D. Hager, Paul E Fenster, P. E. Graves, K. A. Conrad, Steven Goldman

Research output: Contribution to journalArticle

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Abstract

Six subjects were evaluated for the effect of quinine, the I-isomer of quinidine, on digoxin pharmacokinetics. A 1.0-mg intravenous digoxin dose was given before and during quinine administration, followed by the measurement of digoxin serum and urine concentrations for 96 hr after each dose. Quinine reduced digoxin total body clearance by 26% from 2.98 to 2.22 ml/min/kg (p <0.03). Digoxin elimination half-life (t 1/2 ) was lengthened from 34.2 to 51.8 hr, reflecting a 32% decrease in digoxin elimination rate constant (p <0.003). Quinine did not reduce digoxin renal clearance or any volumes of distribution. The amount of digoxin excreted into the urine increased from x̄ = 628.9 μ to x̄ = 772.52 μg (p <0.02). Digoxin nonrenal clearance decreased an average of 55% from 1.2 to 0.55 ml/min/kg (p <0.05). These results suggest that quinine alters digoxin metabolism or biliary secretion, reducing digoxin total body clearance by a mechanism that is qualitatively similar, but quantitatively different, from quinidine.

Original languageEnglish (US)
Pages (from-to)425-430
Number of pages6
JournalClinical Pharmacology and Therapeutics
Volume28
Issue number4
StatePublished - 1980
Externally publishedYes

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Quinine
Digoxin
Quinidine
Urine
Half-Life
Pharmacokinetics
Kidney

ASJC Scopus subject areas

  • Pharmacology

Cite this

Wandell, M., Powell, J. R., Hager, W. D., Fenster, P. E., Graves, P. E., Conrad, K. A., & Goldman, S. (1980). Effect of quinine on digoxin kinetics. Clinical Pharmacology and Therapeutics, 28(4), 425-430.

Effect of quinine on digoxin kinetics. / Wandell, M.; Powell, J. R.; Hager, W. D.; Fenster, Paul E; Graves, P. E.; Conrad, K. A.; Goldman, Steven.

In: Clinical Pharmacology and Therapeutics, Vol. 28, No. 4, 1980, p. 425-430.

Research output: Contribution to journalArticle

Wandell, M, Powell, JR, Hager, WD, Fenster, PE, Graves, PE, Conrad, KA & Goldman, S 1980, 'Effect of quinine on digoxin kinetics', Clinical Pharmacology and Therapeutics, vol. 28, no. 4, pp. 425-430.
Wandell M, Powell JR, Hager WD, Fenster PE, Graves PE, Conrad KA et al. Effect of quinine on digoxin kinetics. Clinical Pharmacology and Therapeutics. 1980;28(4):425-430.
Wandell, M. ; Powell, J. R. ; Hager, W. D. ; Fenster, Paul E ; Graves, P. E. ; Conrad, K. A. ; Goldman, Steven. / Effect of quinine on digoxin kinetics. In: Clinical Pharmacology and Therapeutics. 1980 ; Vol. 28, No. 4. pp. 425-430.
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