Effect of recombinant interleukin-4 on immunoglobulin synthesis in a culture of mononuclear cells isolated from human peripheral blood

L. K. Chelidze, Yu S. Lebedin, E. N. Tsytsikov, V. I. Pivnyuk, R. G. Vasilov

Research output: Contribution to journalArticle

Abstract

The effect of recombinant interleukin-4 on the synthesis of immunoglobulins is studied in a culture of mononuclear cells isolated from peripheral blood of healthy donors and patients with hay fever. It is shown that interleukin-4 stimulates production of IgE in cells of healthy donors, but not of hay fever patients, and does not affect the synthesis of other isotypes in either group. At the same time, increased cell proliferation under the influence of interleukin-4 was observed in cultured cells of both healthy donors and patients.

Original languageEnglish (US)
Pages (from-to)1126-1128
Number of pages3
JournalBulletin of Experimental Biology and Medicine
Volume118
Issue number4
DOIs
StatePublished - Oct 1 1994

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Keywords

  • IgE
  • hay fever
  • interleukin-4

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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