Effect of repetitive transcranial magnetic stimulation on fMRI resting-state connectivity in multiple system atrophy

Ying Hui Chou, Hui You, Han Wang, Yan Ping Zhao, Bo Hou, Nan Kuei Chen, Feng Feng

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

Repetitive transcranial magnetic stimulation (rTMS) is a noninvasive neuromodulation technique that has been used to treat neurological and psychiatric conditions. Although results of rTMS intervention are promising, so far, little is known about the rTMS effect on brain functional networks in clinical populations. In this study, we used a whole-brain connectivity analysis of resting-state functional magnetic resonance imaging data to uncover changes in functional connectivity following rTMS intervention and their association with motor symptoms in patients with multiple system atrophy (MSA). Patients were randomized to active rTMS or sham rTMS groups and completed a 10-session 5-Hz rTMS treatment over the left primary motor area. The results showed significant rTMS-related changes in motor symptoms and functional connectivity. Specifically, (1) significant improvement of motor symptoms was observed in the active rTMS group, but not in the sham rTMS group; and (2) several functional links involving the default mode, cerebellar, and limbic networks exhibited positive changes in functional connectivity in the active rTMS group. Moreover, the positive changes in functional connectivity were associated with improvement in motor symptoms for the active rTMS group. The present findings suggest that rTMS may improve motor symptoms by modulating functional links connecting to the default mode, cerebellar, and limbic networks, inferring a future therapeutic candidate for patients with MSA.

Original languageEnglish (US)
Pages (from-to)451-459
Number of pages9
JournalBrain Connectivity
Volume5
Issue number7
DOIs
StatePublished - Sep 1 2015
Externally publishedYes

Keywords

  • cerebellar network
  • default mode network
  • limbic network
  • Monte-Carlo simulation
  • multiple system atrophy
  • repetitive transcranial magnetic stimulation
  • resting-state functional connectivity
  • Unified Multiple System Atrophy Rating Scale

ASJC Scopus subject areas

  • Neuroscience(all)

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