Nonlactating, nonpregnant Holstein cows were used to examine the effects of an im injection of reserpine. A 5-mg reserpine injection resulted in a rapid (within 0.5 hr) and sustained (at least 24 hr) elevation of serum prolactin. Peak prolactin levels (283 ng/ml) occurred 3 hr postinjection. Serum glucocorticoid and growth hormone concentrations were unaffected by reserpine injection. Two sequential injections of 5 mg of reserpine given at 48-hr intervals gave nearly identical prolactin responses. The prolactin response to reserpine was dose dependent with 1 mg giving approximately 39.5% of the response obtained with 5 mg of reserpine.
|Original language||English (US)|
|Number of pages||4|
|Journal||Proceedings of the Society for Experimental Biology and Medicine|
|State||Published - Jun 1977|
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)