Effect of simple carbohydrates, casein hydrolysate, and a lipid test meal on ethane exhalation rate

A. D. Mooradian, Michael P Habib, F. Dickerson

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

To determine the potential differences in the effect of various nutrients on lipid peroxidation, the ethane exhalation (EE) rate, an index of lipid peroxidation, was measured in rats at 4 (young), 18 (intermediate age), and 24 (aged) mo of age at fasting conditions and after acute ingestion of various test meals. The EE rate (means ± SD) after a 15-h fast was significantly reduced in 24-mo-old rats (2.45 ± 0.44 pmol · min-1 · 100 g body wt-1) and 18-mo-old rats (3.51 ± 0.55 pmol · min-1 · 100 g body wt-1) compared with 4-mo-old rats (4.44 ± 0.66 pmol · min-1 · 100 g body wt-1; P < 0.01). The EE rate significantly increased in 4-mo-old rats after ingestion of 50% (wt/vol) dextrose (8.59 ± 2.9 pmol · min-1 · 100 g body wt-1), 50% casein hydrolysate (6.77 ± 1.23 pmol · min-1 · 100 g body wt-1), and 20% neutral lipid emulsion (7.33 ± 1.96 pmol · min-1 · 100 g body wt-1; P < 0.01). The response of aged rats to these nutrients compared with young rats was reduced by ~50%. A 25% dextrose solution or a 50% solution of sucrose, fructose, maltose, or galactose did not significantly alter EE rate. It is concluded that various macronutrients have a diverse potential of inducing lipid peroxidation. The responsiveness of aged rats to meal-induced enhancement of EE and presumably lipid peroxidation is significantly reduced.

Original languageEnglish (US)
Pages (from-to)1119-1122
Number of pages4
JournalJournal of Applied Physiology
Volume76
Issue number3
StatePublished - 1994
Externally publishedYes

Fingerprint

Exhalation
Ethane
Meals
Carbohydrates
Lipids
Lipid Peroxidation
Eating
Glucose
Food
Maltose
casein hydrolysate
Fructose
Emulsions
Galactose
Sucrose
Fasting

Keywords

  • aging
  • lipid peroxidation
  • macronutrients
  • thermogenesis

ASJC Scopus subject areas

  • Endocrinology
  • Physiology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Effect of simple carbohydrates, casein hydrolysate, and a lipid test meal on ethane exhalation rate. / Mooradian, A. D.; Habib, Michael P; Dickerson, F.

In: Journal of Applied Physiology, Vol. 76, No. 3, 1994, p. 1119-1122.

Research output: Contribution to journalArticle

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