Abstract
A small donor weight is a risk factor for HAT with potential for graft loss. To test this hypothesis, we evaluated outcomes of pediatric liver transplants utilizing donors <20 kg using the UNOS database from 01/2003 to 01/2012 (n = 1311). All isolated liver transplants with whole organ grafts were included. Recipients were divided into four groups based on donor weight: group 1, donor weight <5 kg (n = 34 [2%]); group 2, 5-10 kg (431 [33%]); group 3, 10-15 kg (560 [43%]); and group 4, 15-20 kg (286 [22%]). Actuarial patient survival for the first year post-transplant was significantly lower in groups 1 and 2 compared to groups 3 and 4 (p = 0.002), similarly the one-yr graft function (p < 0.0001). The difference was due to graft loss within the first month for groups 1 and 2. HAT was significantly higher in groups 1 and 2 compared to others (p = 0.0006). Logistic regression analysis demonstrated donor weight as the most predictive factor with analysis of the ROC curve showing a cutoff point at 7.8 kg. The donor-recipient weight ratio did, in none of the models, gain statistical significance.
Original language | English (US) |
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Pages (from-to) | 366-370 |
Number of pages | 5 |
Journal | Pediatric transplantation |
Volume | 19 |
Issue number | 4 |
DOIs | |
State | Published - Jun 1 2015 |
Keywords
- cadaveric donor
- graft survival
- hepatic artery thrombosis
- liver allograft
- pediatric liver transplant
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
- Transplantation