Abstract
A small donor weight is a risk factor for HAT with potential for graft loss. To test this hypothesis, we evaluated outcomes of pediatric liver transplants utilizing donors <20 kg using the UNOS database from 01/2003 to 01/2012 (n = 1311). All isolated liver transplants with whole organ grafts were included. Recipients were divided into four groups based on donor weight: group 1, donor weight <5 kg (n = 34 [2%]); group 2, 5-10 kg (431 [33%]); group 3, 10-15 kg (560 [43%]); and group 4, 15-20 kg (286 [22%]). Actuarial patient survival for the first year post-transplant was significantly lower in groups 1 and 2 compared to groups 3 and 4 (p = 0.002), similarly the one-yr graft function (p < 0.0001). The difference was due to graft loss within the first month for groups 1 and 2. HAT was significantly higher in groups 1 and 2 compared to others (p = 0.0006). Logistic regression analysis demonstrated donor weight as the most predictive factor with analysis of the ROC curve showing a cutoff point at 7.8 kg. The donor-recipient weight ratio did, in none of the models, gain statistical significance.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 366-370 |
| Number of pages | 5 |
| Journal | Pediatric Transplantation |
| Volume | 19 |
| Issue number | 4 |
| DOIs | |
| State | Published - Jun 1 2015 |
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Keywords
- cadaveric donor
- graft survival
- hepatic artery thrombosis
- liver allograft
- pediatric liver transplant
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
- Transplantation
Cite this
Effect of small donor weight and donor-recipient weight ratio on the outcome of liver transplantation in children. / Desai, Chirag S.; Sharma, Sanjay; Gruessner, Angelika C; Fishbein, Thomas; Kaufman, Stuart; Khan, Khalid M.
In: Pediatric Transplantation, Vol. 19, No. 4, 01.06.2015, p. 366-370.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effect of small donor weight and donor-recipient weight ratio on the outcome of liver transplantation in children
AU - Desai, Chirag S.
AU - Sharma, Sanjay
AU - Gruessner, Angelika C
AU - Fishbein, Thomas
AU - Kaufman, Stuart
AU - Khan, Khalid M.
PY - 2015/6/1
Y1 - 2015/6/1
N2 - A small donor weight is a risk factor for HAT with potential for graft loss. To test this hypothesis, we evaluated outcomes of pediatric liver transplants utilizing donors <20 kg using the UNOS database from 01/2003 to 01/2012 (n = 1311). All isolated liver transplants with whole organ grafts were included. Recipients were divided into four groups based on donor weight: group 1, donor weight <5 kg (n = 34 [2%]); group 2, 5-10 kg (431 [33%]); group 3, 10-15 kg (560 [43%]); and group 4, 15-20 kg (286 [22%]). Actuarial patient survival for the first year post-transplant was significantly lower in groups 1 and 2 compared to groups 3 and 4 (p = 0.002), similarly the one-yr graft function (p < 0.0001). The difference was due to graft loss within the first month for groups 1 and 2. HAT was significantly higher in groups 1 and 2 compared to others (p = 0.0006). Logistic regression analysis demonstrated donor weight as the most predictive factor with analysis of the ROC curve showing a cutoff point at 7.8 kg. The donor-recipient weight ratio did, in none of the models, gain statistical significance.
AB - A small donor weight is a risk factor for HAT with potential for graft loss. To test this hypothesis, we evaluated outcomes of pediatric liver transplants utilizing donors <20 kg using the UNOS database from 01/2003 to 01/2012 (n = 1311). All isolated liver transplants with whole organ grafts were included. Recipients were divided into four groups based on donor weight: group 1, donor weight <5 kg (n = 34 [2%]); group 2, 5-10 kg (431 [33%]); group 3, 10-15 kg (560 [43%]); and group 4, 15-20 kg (286 [22%]). Actuarial patient survival for the first year post-transplant was significantly lower in groups 1 and 2 compared to groups 3 and 4 (p = 0.002), similarly the one-yr graft function (p < 0.0001). The difference was due to graft loss within the first month for groups 1 and 2. HAT was significantly higher in groups 1 and 2 compared to others (p = 0.0006). Logistic regression analysis demonstrated donor weight as the most predictive factor with analysis of the ROC curve showing a cutoff point at 7.8 kg. The donor-recipient weight ratio did, in none of the models, gain statistical significance.
KW - cadaveric donor
KW - graft survival
KW - hepatic artery thrombosis
KW - liver allograft
KW - pediatric liver transplant
UR - http://www.scopus.com/inward/record.url?scp=84928993507&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84928993507&partnerID=8YFLogxK
U2 - 10.1111/petr.12459
DO - 10.1111/petr.12459
M3 - Article
C2 - 25819141
AN - SCOPUS:84928993507
VL - 19
SP - 366
EP - 370
JO - Pediatric Transplantation
JF - Pediatric Transplantation
SN - 1397-3142
IS - 4
ER -