Effect of sound on gap-junction-based intercellular signaling

Calcium waves under acoustic irradiation

Pierre A Deymier, N. Swinteck, Keith A Runge, A. Deymier-Black, J. B. Hoying

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

We present a previously unrecognized effect of sound waves on gap-junction-based intercellular signaling such as in biological tissues composed of endothelial cells. We suggest that sound irradiation may, through temporal and spatial modulation of cell-to-cell conductance, create intercellular calcium waves with unidirectional signal propagation associated with nonconventional topologies. Nonreciprocity in calcium wave propagation induced by sound wave irradiation is demonstrated in the case of a linear and a nonlinear reaction-diffusion model. This demonstration should be applicable to other types of gap-junction-based intercellular signals, and it is thought that it should be of help in interpreting a broad range of biological phenomena associated with the beneficial therapeutic effects of sound irradiation and possibly the harmful effects of sound waves on health.

Original languageEnglish (US)
Article number052711
JournalPhysical Review E - Statistical, Nonlinear, and Soft Matter Physics
Volume92
Issue number5
DOIs
StatePublished - Nov 9 2015

Fingerprint

Gap Junction
Calcium
sound waves
Irradiation
calcium
Acoustics
irradiation
acoustics
cells
health
wave propagation
topology
Endothelial Cells
Biological Tissue
Reaction-diffusion Model
Cell
modulation
Conductance
propagation
Wave Propagation

ASJC Scopus subject areas

  • Condensed Matter Physics
  • Statistical and Nonlinear Physics
  • Statistics and Probability

Cite this

Effect of sound on gap-junction-based intercellular signaling : Calcium waves under acoustic irradiation. / Deymier, Pierre A; Swinteck, N.; Runge, Keith A; Deymier-Black, A.; Hoying, J. B.

In: Physical Review E - Statistical, Nonlinear, and Soft Matter Physics, Vol. 92, No. 5, 052711, 09.11.2015.

Research output: Contribution to journalArticle

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