Effect of sound on gap-junction-based intercellular signaling: Calcium waves under acoustic irradiation

Pierre A Deymier, N. Swinteck, Keith A Runge, A. Deymier-Black, J. B. Hoying

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Abstract

We present a previously unrecognized effect of sound waves on gap-junction-based intercellular signaling such as in biological tissues composed of endothelial cells. We suggest that sound irradiation may, through temporal and spatial modulation of cell-to-cell conductance, create intercellular calcium waves with unidirectional signal propagation associated with nonconventional topologies. Nonreciprocity in calcium wave propagation induced by sound wave irradiation is demonstrated in the case of a linear and a nonlinear reaction-diffusion model. This demonstration should be applicable to other types of gap-junction-based intercellular signals, and it is thought that it should be of help in interpreting a broad range of biological phenomena associated with the beneficial therapeutic effects of sound irradiation and possibly the harmful effects of sound waves on health.

Original languageEnglish (US)
Article number052711
JournalPhysical Review E - Statistical, Nonlinear, and Soft Matter Physics
Volume92
Issue number5
DOIs
Publication statusPublished - Nov 9 2015

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ASJC Scopus subject areas

  • Condensed Matter Physics
  • Statistical and Nonlinear Physics
  • Statistics and Probability

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