Effect of sub-micron pillar array on DNA kinetics in a free-solution capillary electrophoresis microsystem

Yick Chuen Chan, Yi Kuen Lee, Man Wong, Yitshak Zohar

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

This paper presents an experimental and numerical study of the effect of a sub-micron pillar array, embedded in the separation channel, on DNA kinetics in a free-solution capillary electrophoresis microsystem. DNA plugs have been observed to migrate with different velocity depending on the cross-sectional shape of the pillars. This velocity variation can be partly explained by the electric field re-distribution due to the pillar array. Numerical simulations have been carried out to verify the effect of the sub-micron pillar geometry on the electric field distribution, and the computations of DNA plug velocity are qualitatively consistent with the measurements.

Original languageEnglish (US)
Title of host publicationMicro Total Analysis Systems - Proceedings of MicroTAS 2005 Conference
Subtitle of host publication9th International Conference on Miniaturized Systems for Chemistry and Life Sciences
PublisherTransducer Research Foundation
Pages337-339
Number of pages3
ISBN (Print)0974361119, 9780974361116
StatePublished - Jan 1 2005
Event9th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2005 - Boston, MA, United States
Duration: Oct 9 2005Oct 13 2005

Publication series

NameMicro Total Analysis Systems - Proceedings of MicroTAS 2005 Conference: 9th International Conference on Miniaturized Systems for Chemistry and Life Sciences
Volume1

Other

Other9th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2005
CountryUnited States
CityBoston, MA
Period10/9/0510/13/05

Keywords

  • DNA kinetics
  • Electrophoresis
  • Free-solution
  • Sub-micron pillars

ASJC Scopus subject areas

  • Chemical Engineering (miscellaneous)
  • Bioengineering

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