Effect of the ouabain-quinidine interaction of left ventricular and left atrial function in conscious dogs

Steven Goldman, W. D. Hager, M. Olajos, D. Perrier, Michael Mayersohn

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4 Citations (Scopus)

Abstract

The effect of the ouabain-quinidine interaction was examined in 10 conscious dogs. Left ventricular (LV) pressure, LV dP/dt, LV diameter and left atrial (LA) diameter were measured with high-fidelity micromanometers and sonomicrometer crystals. Ouabain, 0.025 mg/kg, significantly (p < 0.05) increased LV dP/dt, LV and LA fractional shortening and LV and LA velocity of circumferential fiber shortening (Vcf). In a separate experiment, quinidine was administered as a bolus dose, 3.85 mg/kg, followed by an infusion, 0.28 mg/kg/min. This resulted in steady-state quinidine concentrations that produced no change in wall motion or hemodynamics. When ouabain was given 1 hour into the quinidine infusion, only LV dP/dt increased significantly (p < 0.05). Ouabain alone increased LV dP/dt 26.4 ± 3.5%, whereas ouabain during the quinidine infusion increased it by 9.5 ± 2.3%. Similar differences were seen in the response to ouabain in the absence and presence of quinidine: LV Vcf, 22.4 ± 4.9% vs 6.0 ± 2.1%, LV fractional shortening, 23.1 ± 4.6% vs 5.8 ± 2.1%, LA Vcf, 22.7 ± 5.9 vs 4.6 ± 2.0% and LA fractional shortening, 21.8 ± 7% vs 7.8 ± 3.3%. Thus, in the presence of quinidine the increase in intropy usually seen with ouabain was markedly attenuated. These data suggest that the quinidine-induced increase in digoxin serum concentrations is accompanied by a decrease in the contractile response of the heart to digoxin.

Original languageEnglish (US)
Pages (from-to)1054-1058
Number of pages5
JournalCirculation
Volume67
Issue number5
StatePublished - 1983
Externally publishedYes

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Left Atrial Function
Quinidine
Ouabain
Dogs
Digoxin
Ventricular Pressure
Hemodynamics

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Effect of the ouabain-quinidine interaction of left ventricular and left atrial function in conscious dogs. / Goldman, Steven; Hager, W. D.; Olajos, M.; Perrier, D.; Mayersohn, Michael.

In: Circulation, Vol. 67, No. 5, 1983, p. 1054-1058.

Research output: Contribution to journalArticle

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abstract = "The effect of the ouabain-quinidine interaction was examined in 10 conscious dogs. Left ventricular (LV) pressure, LV dP/dt, LV diameter and left atrial (LA) diameter were measured with high-fidelity micromanometers and sonomicrometer crystals. Ouabain, 0.025 mg/kg, significantly (p < 0.05) increased LV dP/dt, LV and LA fractional shortening and LV and LA velocity of circumferential fiber shortening (Vcf). In a separate experiment, quinidine was administered as a bolus dose, 3.85 mg/kg, followed by an infusion, 0.28 mg/kg/min. This resulted in steady-state quinidine concentrations that produced no change in wall motion or hemodynamics. When ouabain was given 1 hour into the quinidine infusion, only LV dP/dt increased significantly (p < 0.05). Ouabain alone increased LV dP/dt 26.4 ± 3.5{\%}, whereas ouabain during the quinidine infusion increased it by 9.5 ± 2.3{\%}. Similar differences were seen in the response to ouabain in the absence and presence of quinidine: LV Vcf, 22.4 ± 4.9{\%} vs 6.0 ± 2.1{\%}, LV fractional shortening, 23.1 ± 4.6{\%} vs 5.8 ± 2.1{\%}, LA Vcf, 22.7 ± 5.9 vs 4.6 ± 2.0{\%} and LA fractional shortening, 21.8 ± 7{\%} vs 7.8 ± 3.3{\%}. Thus, in the presence of quinidine the increase in intropy usually seen with ouabain was markedly attenuated. These data suggest that the quinidine-induced increase in digoxin serum concentrations is accompanied by a decrease in the contractile response of the heart to digoxin.",
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N2 - The effect of the ouabain-quinidine interaction was examined in 10 conscious dogs. Left ventricular (LV) pressure, LV dP/dt, LV diameter and left atrial (LA) diameter were measured with high-fidelity micromanometers and sonomicrometer crystals. Ouabain, 0.025 mg/kg, significantly (p < 0.05) increased LV dP/dt, LV and LA fractional shortening and LV and LA velocity of circumferential fiber shortening (Vcf). In a separate experiment, quinidine was administered as a bolus dose, 3.85 mg/kg, followed by an infusion, 0.28 mg/kg/min. This resulted in steady-state quinidine concentrations that produced no change in wall motion or hemodynamics. When ouabain was given 1 hour into the quinidine infusion, only LV dP/dt increased significantly (p < 0.05). Ouabain alone increased LV dP/dt 26.4 ± 3.5%, whereas ouabain during the quinidine infusion increased it by 9.5 ± 2.3%. Similar differences were seen in the response to ouabain in the absence and presence of quinidine: LV Vcf, 22.4 ± 4.9% vs 6.0 ± 2.1%, LV fractional shortening, 23.1 ± 4.6% vs 5.8 ± 2.1%, LA Vcf, 22.7 ± 5.9 vs 4.6 ± 2.0% and LA fractional shortening, 21.8 ± 7% vs 7.8 ± 3.3%. Thus, in the presence of quinidine the increase in intropy usually seen with ouabain was markedly attenuated. These data suggest that the quinidine-induced increase in digoxin serum concentrations is accompanied by a decrease in the contractile response of the heart to digoxin.

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