Effect of tubulin diffusion on polymerization of microtubules

Pierre A Deymier, Y. Yang, J. Hoying

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The dynamics of microtubules (MT’s) growing from a nucleation center is simulated with a kinetic Monte Carlo model that includes tubulin diffusion. In the limit of fast diffusion (homogeneous tubulin concentration), MT growth is synchronous and bounded. The microtubules form an aster with a monotonously decreasing long-time distribution of lengths. Slow tubulin diffusion leads to rapid dephasing in the growth dynamics, unbounded growth of some MT’s, spatial inhomogeneities, and morphological change toward a morphology with bounded short MT†™s located in the nucleation center and unbounded long MT’s with narrowly distributed lengths. The transition from unbounded to bounded growth is driven by the competition between the reaction rate of the tubulin assembly and the tubulin’s diffusion rate. While the present study reports the effect of the tubulin diffusion coefficient on the transition, the results of the simulations are qualitatively comparable to the morphological and dynamical changes of centrosome-nucleated MT’s from interphase to mitosis in cellular systems where the transition is regulated by the reaction rates.

Original languageEnglish (US)
Article number021906
JournalPhysical Review E - Statistical, Nonlinear, and Soft Matter Physics
Volume72
Issue number2
DOIs
StatePublished - Aug 2005

Fingerprint

Microtubules
Polymerization
Tubulin
polymerization
reaction kinetics
nucleation
mitosis
Reaction Rate
Growth
Nucleation
inhomogeneity
Fast Diffusion
diffusion coefficient
assembly
Kinetic Monte Carlo
Centrosome
Cellular Systems
Interphase
Mitosis
Inhomogeneity

ASJC Scopus subject areas

  • Physics and Astronomy(all)
  • Condensed Matter Physics
  • Statistical and Nonlinear Physics
  • Mathematical Physics
  • Medicine(all)

Cite this

Effect of tubulin diffusion on polymerization of microtubules. / Deymier, Pierre A; Yang, Y.; Hoying, J.

In: Physical Review E - Statistical, Nonlinear, and Soft Matter Physics, Vol. 72, No. 2, 021906, 08.2005.

Research output: Contribution to journalArticle

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