Effect of vitamin E on cell-mediated immune responses and serum corticosterone in young and maturing mice

T. S. Lim, N. Putt, D. Safranski, C. Chung, R. R. Watson

Research output: Contribution to journalArticle

39 Scopus citations

Abstract

A high vitamin E diet altered cell-mediated immune responses of maturing 0,12118 BALB/c mice. Serum corticosterone concentrations in these animals were also determined because of the pharmacological effect the glucocorticoid hormone has on immune systems. Mice receiving high vitamin E diet (twenty times higher than the vitamin E concentration in control diet) showed significant increase in antibody-dependent cellular cytotoxicity (ADCC) activity within a week after initiation of the diet. Adult levels of spleen and intestinal ADCC activities were reached at a much younger age in these high vitamin 0,12642 E-treated animals. In addition, there was a good correlation between increase in spleen and intestinal ADCC activities and the sigificantly lower than control concentration of serum corticosterone in these mice. However, after prolonged consumption of high vitamin E diet, decrease in ADCC activity was observed in these mice. No significant differences in PHA-induced spleen lymphocytes [ 3H]-thymidine incorporation, along with a decrease in serum corticosterone levels, were observed in mice given either 0,13147 high vitamin E or the control diets throughout most study periods.

Original languageEnglish (US)
Pages (from-to)289-295
Number of pages7
JournalImmunology
Volume44
Issue number2
StatePublished - Nov 9 1981
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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