Effect of vitamin E on exhaled ethane in cigarette smokers

Michael P Habib, Laura J. Tank, Lisa C. Lane, Harinder S. Garewal

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Study objectives: We hypothesized that micronutrient antioxidant intake may be one factor determining the development of significant COPD. Vitamin E was administered to smokers to determine if exhaled ethane was reduced and if ethane correlated with measures of lung function. Study design: Longitudinal placebo lead-in trial with posttreatment observation period. Setting: Tucson Veterans Affairs Medical Center. Participants: Twenty-nine current stable smokers having no interest in smoking cessation. Interventions: Spirometry, exhaled breath ethane measurements, and vitamin E and β-carotene plasma levels followed by 3 weeks of placebo with repeat plasma vitamin levels and ethane measurements; next, 3 weeks of vitamin E (dl-α-tocopherol), 400 IU po bid followed by plasma vitamin levels and breath ethane measurements; finally, 3 weeks without vitamins followed by breath ethane and plasma vitamin levels. Results: Vitamin E treatment did not reduce ethane significantly. Exhaled ethane levels (mean + SD: pm/min/kg) were as follows: baseline, 7.39 ± 5.39; after run-in period, 6.86 ± 4.09; after vitamin E, 6.36 ± 3.02; and final, 7.23 ± 4.63. After vitamin E therapy, a significant negative correlation existed between exhaled ethane and FEV1/FVC. Pack- years of smoking at baseline and after vitamin E were significantly associated with ethane exhaled. Initial lung function was not significantly negatively associated with vitamin E-induced changes in exhaled ethane but a negative trend was found. Conclusions: Vitamin E alone, unlike the combination of vitamins C, E, and β-carotene, failed to reduced exhaled ethane in cigarette smokers. Exhaled ethane was correlated with pack-years of smoking. Smokers whose ethane values were found to fall the most tended to have better preserved lung function.

Original languageEnglish (US)
Pages (from-to)684-690
Number of pages7
JournalChest
Volume115
Issue number3
DOIs
StatePublished - 1999

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Ethane
Vitamin E
Tobacco Products
Vitamins
Carotenoids
Lung
Smoking
Placebos
Tocopherols
Micronutrients
Spirometry
Veterans
Smoking Cessation
Chronic Obstructive Pulmonary Disease
Ascorbic Acid
Longitudinal Studies

Keywords

  • Antioxidants
  • COPD
  • Vitamin E

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Effect of vitamin E on exhaled ethane in cigarette smokers. / Habib, Michael P; Tank, Laura J.; Lane, Lisa C.; Garewal, Harinder S.

In: Chest, Vol. 115, No. 3, 1999, p. 684-690.

Research output: Contribution to journalArticle

Habib, MP, Tank, LJ, Lane, LC & Garewal, HS 1999, 'Effect of vitamin E on exhaled ethane in cigarette smokers', Chest, vol. 115, no. 3, pp. 684-690. https://doi.org/10.1378/chest.115.3.684
Habib, Michael P ; Tank, Laura J. ; Lane, Lisa C. ; Garewal, Harinder S. / Effect of vitamin E on exhaled ethane in cigarette smokers. In: Chest. 1999 ; Vol. 115, No. 3. pp. 684-690.
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abstract = "Study objectives: We hypothesized that micronutrient antioxidant intake may be one factor determining the development of significant COPD. Vitamin E was administered to smokers to determine if exhaled ethane was reduced and if ethane correlated with measures of lung function. Study design: Longitudinal placebo lead-in trial with posttreatment observation period. Setting: Tucson Veterans Affairs Medical Center. Participants: Twenty-nine current stable smokers having no interest in smoking cessation. Interventions: Spirometry, exhaled breath ethane measurements, and vitamin E and β-carotene plasma levels followed by 3 weeks of placebo with repeat plasma vitamin levels and ethane measurements; next, 3 weeks of vitamin E (dl-α-tocopherol), 400 IU po bid followed by plasma vitamin levels and breath ethane measurements; finally, 3 weeks without vitamins followed by breath ethane and plasma vitamin levels. Results: Vitamin E treatment did not reduce ethane significantly. Exhaled ethane levels (mean + SD: pm/min/kg) were as follows: baseline, 7.39 ± 5.39; after run-in period, 6.86 ± 4.09; after vitamin E, 6.36 ± 3.02; and final, 7.23 ± 4.63. After vitamin E therapy, a significant negative correlation existed between exhaled ethane and FEV1/FVC. Pack- years of smoking at baseline and after vitamin E were significantly associated with ethane exhaled. Initial lung function was not significantly negatively associated with vitamin E-induced changes in exhaled ethane but a negative trend was found. Conclusions: Vitamin E alone, unlike the combination of vitamins C, E, and β-carotene, failed to reduced exhaled ethane in cigarette smokers. Exhaled ethane was correlated with pack-years of smoking. Smokers whose ethane values were found to fall the most tended to have better preserved lung function.",
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AB - Study objectives: We hypothesized that micronutrient antioxidant intake may be one factor determining the development of significant COPD. Vitamin E was administered to smokers to determine if exhaled ethane was reduced and if ethane correlated with measures of lung function. Study design: Longitudinal placebo lead-in trial with posttreatment observation period. Setting: Tucson Veterans Affairs Medical Center. Participants: Twenty-nine current stable smokers having no interest in smoking cessation. Interventions: Spirometry, exhaled breath ethane measurements, and vitamin E and β-carotene plasma levels followed by 3 weeks of placebo with repeat plasma vitamin levels and ethane measurements; next, 3 weeks of vitamin E (dl-α-tocopherol), 400 IU po bid followed by plasma vitamin levels and breath ethane measurements; finally, 3 weeks without vitamins followed by breath ethane and plasma vitamin levels. Results: Vitamin E treatment did not reduce ethane significantly. Exhaled ethane levels (mean + SD: pm/min/kg) were as follows: baseline, 7.39 ± 5.39; after run-in period, 6.86 ± 4.09; after vitamin E, 6.36 ± 3.02; and final, 7.23 ± 4.63. After vitamin E therapy, a significant negative correlation existed between exhaled ethane and FEV1/FVC. Pack- years of smoking at baseline and after vitamin E were significantly associated with ethane exhaled. Initial lung function was not significantly negatively associated with vitamin E-induced changes in exhaled ethane but a negative trend was found. Conclusions: Vitamin E alone, unlike the combination of vitamins C, E, and β-carotene, failed to reduced exhaled ethane in cigarette smokers. Exhaled ethane was correlated with pack-years of smoking. Smokers whose ethane values were found to fall the most tended to have better preserved lung function.

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