Abstract
Study objectives: We hypothesized that micronutrient antioxidant intake may be one factor determining the development of significant COPD. Vitamin E was administered to smokers to determine if exhaled ethane was reduced and if ethane correlated with measures of lung function. Study design: Longitudinal placebo lead-in trial with posttreatment observation period. Setting: Tucson Veterans Affairs Medical Center. Participants: Twenty-nine current stable smokers having no interest in smoking cessation. Interventions: Spirometry, exhaled breath ethane measurements, and vitamin E and β-carotene plasma levels followed by 3 weeks of placebo with repeat plasma vitamin levels and ethane measurements; next, 3 weeks of vitamin E (dl-α-tocopherol), 400 IU po bid followed by plasma vitamin levels and breath ethane measurements; finally, 3 weeks without vitamins followed by breath ethane and plasma vitamin levels. Results: Vitamin E treatment did not reduce ethane significantly. Exhaled ethane levels (mean + SD: pm/min/kg) were as follows: baseline, 7.39 ± 5.39; after run-in period, 6.86 ± 4.09; after vitamin E, 6.36 ± 3.02; and final, 7.23 ± 4.63. After vitamin E therapy, a significant negative correlation existed between exhaled ethane and FEV1/FVC. Pack- years of smoking at baseline and after vitamin E were significantly associated with ethane exhaled. Initial lung function was not significantly negatively associated with vitamin E-induced changes in exhaled ethane but a negative trend was found. Conclusions: Vitamin E alone, unlike the combination of vitamins C, E, and β-carotene, failed to reduced exhaled ethane in cigarette smokers. Exhaled ethane was correlated with pack-years of smoking. Smokers whose ethane values were found to fall the most tended to have better preserved lung function.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 684-690 |
| Number of pages | 7 |
| Journal | Chest |
| Volume | 115 |
| Issue number | 3 |
| DOIs | |
| State | Published - 1999 |
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Keywords
- Antioxidants
- COPD
- Vitamin E
ASJC Scopus subject areas
- Pulmonary and Respiratory Medicine
Cite this
Effect of vitamin E on exhaled ethane in cigarette smokers. / Habib, Michael P; Tank, Laura J.; Lane, Lisa C.; Garewal, Harinder S.
In: Chest, Vol. 115, No. 3, 1999, p. 684-690.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effect of vitamin E on exhaled ethane in cigarette smokers
AU - Habib, Michael P
AU - Tank, Laura J.
AU - Lane, Lisa C.
AU - Garewal, Harinder S.
PY - 1999
Y1 - 1999
N2 - Study objectives: We hypothesized that micronutrient antioxidant intake may be one factor determining the development of significant COPD. Vitamin E was administered to smokers to determine if exhaled ethane was reduced and if ethane correlated with measures of lung function. Study design: Longitudinal placebo lead-in trial with posttreatment observation period. Setting: Tucson Veterans Affairs Medical Center. Participants: Twenty-nine current stable smokers having no interest in smoking cessation. Interventions: Spirometry, exhaled breath ethane measurements, and vitamin E and β-carotene plasma levels followed by 3 weeks of placebo with repeat plasma vitamin levels and ethane measurements; next, 3 weeks of vitamin E (dl-α-tocopherol), 400 IU po bid followed by plasma vitamin levels and breath ethane measurements; finally, 3 weeks without vitamins followed by breath ethane and plasma vitamin levels. Results: Vitamin E treatment did not reduce ethane significantly. Exhaled ethane levels (mean + SD: pm/min/kg) were as follows: baseline, 7.39 ± 5.39; after run-in period, 6.86 ± 4.09; after vitamin E, 6.36 ± 3.02; and final, 7.23 ± 4.63. After vitamin E therapy, a significant negative correlation existed between exhaled ethane and FEV1/FVC. Pack- years of smoking at baseline and after vitamin E were significantly associated with ethane exhaled. Initial lung function was not significantly negatively associated with vitamin E-induced changes in exhaled ethane but a negative trend was found. Conclusions: Vitamin E alone, unlike the combination of vitamins C, E, and β-carotene, failed to reduced exhaled ethane in cigarette smokers. Exhaled ethane was correlated with pack-years of smoking. Smokers whose ethane values were found to fall the most tended to have better preserved lung function.
AB - Study objectives: We hypothesized that micronutrient antioxidant intake may be one factor determining the development of significant COPD. Vitamin E was administered to smokers to determine if exhaled ethane was reduced and if ethane correlated with measures of lung function. Study design: Longitudinal placebo lead-in trial with posttreatment observation period. Setting: Tucson Veterans Affairs Medical Center. Participants: Twenty-nine current stable smokers having no interest in smoking cessation. Interventions: Spirometry, exhaled breath ethane measurements, and vitamin E and β-carotene plasma levels followed by 3 weeks of placebo with repeat plasma vitamin levels and ethane measurements; next, 3 weeks of vitamin E (dl-α-tocopherol), 400 IU po bid followed by plasma vitamin levels and breath ethane measurements; finally, 3 weeks without vitamins followed by breath ethane and plasma vitamin levels. Results: Vitamin E treatment did not reduce ethane significantly. Exhaled ethane levels (mean + SD: pm/min/kg) were as follows: baseline, 7.39 ± 5.39; after run-in period, 6.86 ± 4.09; after vitamin E, 6.36 ± 3.02; and final, 7.23 ± 4.63. After vitamin E therapy, a significant negative correlation existed between exhaled ethane and FEV1/FVC. Pack- years of smoking at baseline and after vitamin E were significantly associated with ethane exhaled. Initial lung function was not significantly negatively associated with vitamin E-induced changes in exhaled ethane but a negative trend was found. Conclusions: Vitamin E alone, unlike the combination of vitamins C, E, and β-carotene, failed to reduced exhaled ethane in cigarette smokers. Exhaled ethane was correlated with pack-years of smoking. Smokers whose ethane values were found to fall the most tended to have better preserved lung function.
KW - Antioxidants
KW - COPD
KW - Vitamin E
UR - http://www.scopus.com/inward/record.url?scp=0033060918&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033060918&partnerID=8YFLogxK
U2 - 10.1378/chest.115.3.684
DO - 10.1378/chest.115.3.684
M3 - Article
C2 - 10084476
AN - SCOPUS:0033060918
VL - 115
SP - 684
EP - 690
JO - Chest
JF - Chest
SN - 0012-3692
IS - 3
ER -