Effect of volatile anesthetics on protein synthesis and secretion by rat hepatocyte suspensions

A. B. Direnzo, C. R. Adamson, A. J. Fandolfi, K. Brendel, G. Krack

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

The effect of volatile anesthetics on protein synthesis and secretion by isolated rat hepatocytes in suspension was investigated. Halothane and enflurane inhibited protein synthesis in a dose-dependent manner. Diethyl ether had little effect on protein synthesis while isoflurane caused a mild inhibition. This effect was more pronounced in hepatocytes from phenobarbital treated male rats when compared to hepatocytes from control rats. Protein synthesis in hepatocytes from phenobarbital treated female rats was inhibited similar to that seen with control male rat hepatocytes. Isoflurane, enflurane, and halothane also caused a dose-dependent inhibition of protein secretion, while diethyl ether was only mildy inhibitory. From these studies it appears that inhibition of protein synthesis and secretion might be an early and sensitive indicator of cellular injury by volatile anesthetics.

Original languageEnglish (US)
Pages (from-to)223-237
Number of pages15
JournalDrug and Chemical Toxicology
Volume9
Issue number3-4
DOIs
StatePublished - Jan 1 1986

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology
  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis
  • Chemical Health and Safety

Fingerprint Dive into the research topics of 'Effect of volatile anesthetics on protein synthesis and secretion by rat hepatocyte suspensions'. Together they form a unique fingerprint.

  • Cite this