Effect of volatile anesthetics on protein synthesis and secretion by rat hepatocyte suspensions

A. B. Direnzo, C. R. Adamson, A Jay Gandolfi, K. Brendel, G. Krack

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The effect of volatile anesthetics on protein synthesis and secretion by isolated rat hepatocytes in suspension was investigated. Halothane and enflurane inhibited protein synthesis in a dose-dependent manner. Diethyl ether had little effect on protein synthesis while isoflurane caused a mild inhibition. This effect was more pronounced in hepatocytes from phenobarbital treated male rats when compared to hepatocytes from control rats. Protein synthesis in hepatocytes from phenobarbital treated female rats was inhibited similar to that seen with control male rat hepatocytes. Isoflurane, enflurane, and halothane also caused a dose-dependent inhibition of protein secretion, while diethyl ether was only mildy inhibitory. From these studies it appears that inhibition of protein synthesis and secretion might be an early and sensitive indicator of cellular injury by volatile anesthetics.

Original languageEnglish (US)
Pages (from-to)223-237
Number of pages15
JournalDrug and Chemical Toxicology
Volume9
Issue number3-4
DOIs
StatePublished - 1986

Fingerprint

Anesthetics
Rats
Hepatocytes
Suspensions
Proteins
Rat control
Enflurane
Isoflurane
Halothane
Phenobarbital
Ether
Ethers
Wounds and Injuries

ASJC Scopus subject areas

  • Pharmacology
  • Health, Toxicology and Mutagenesis
  • Toxicology
  • Public Health, Environmental and Occupational Health
  • Chemical Health and Safety
  • Chemistry(all)

Cite this

Effect of volatile anesthetics on protein synthesis and secretion by rat hepatocyte suspensions. / Direnzo, A. B.; Adamson, C. R.; Gandolfi, A Jay; Brendel, K.; Krack, G.

In: Drug and Chemical Toxicology, Vol. 9, No. 3-4, 1986, p. 223-237.

Research output: Contribution to journalArticle

Direnzo, A. B. ; Adamson, C. R. ; Gandolfi, A Jay ; Brendel, K. ; Krack, G. / Effect of volatile anesthetics on protein synthesis and secretion by rat hepatocyte suspensions. In: Drug and Chemical Toxicology. 1986 ; Vol. 9, No. 3-4. pp. 223-237.
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