Effectiveness of image-guided radiotherapy for laryngeal sparing in head and neck cancer

Nam P. Nguyen, Misty Ceizyk, Paul Vos, Vincent Vinh-Hung, Rick Davis, Anand Desai, Dave Abraham, Shane P. Krafft, Siyoung Jang, Christopher J. Watchman, Lars Ewell, Russ Hamilton, Lexie Smith-Raymond

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

We would like to compare the effectiveness of image-guided (IGRT) and intensity-modulated (IMRT) radiotherapy to spare the larynx in head and neck cancer patients. A retrospective review of 48 patients undergoing radiation for non-laryngeal and non-hypopharyngeal head and neck cancers. Mean laryngeal and hypopharyngeal dose was compared between 11 patients treated with IMRT and 37 patients treated with IGRT. Mean laryngeal dose was, respectively, 41.2 Gy and 22.8 Gy for the IMRT and IGRT technique (p < 0.001). The radiation dose to the middle and inferior pharyngeal muscles was also significantly reduced with the IGRT technique. Mean pharyngeal dose was, respectively, 52 Gy and 26 Gy for the IMRT and IGRT technique (p = 0.0001). Laryngeal sparing IGRT technique for head and neck cancer minimizes radiotherapy dose to the larynx and pharynx without sacrificing target coverage, even in the presence of neck lymph nodes.

Original languageEnglish (US)
Pages (from-to)283-286
Number of pages4
JournalOral Oncology
Volume46
Issue number4
DOIs
StatePublished - Apr 1 2010

Keywords

  • Head and neck cancer
  • IGRT
  • Laryngeal sparing

ASJC Scopus subject areas

  • Oral Surgery
  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'Effectiveness of image-guided radiotherapy for laryngeal sparing in head and neck cancer'. Together they form a unique fingerprint.

Cite this