Effectiveness of image-guided radiotherapy for laryngeal sparing in head and neck cancer

Nam P. Nguyen, Misty Ceizyk, Paul Vos, Vincent Vinh-Hung, Rick Davis, Anand Desai, Dave Abraham, Shane P. Krafft, Siyoung Jang, Christopher J Watchman, Lars Ewell, Russell J Hamilton, Lexie Smith-Raymond

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

We would like to compare the effectiveness of image-guided (IGRT) and intensity-modulated (IMRT) radiotherapy to spare the larynx in head and neck cancer patients. A retrospective review of 48 patients undergoing radiation for non-laryngeal and non-hypopharyngeal head and neck cancers. Mean laryngeal and hypopharyngeal dose was compared between 11 patients treated with IMRT and 37 patients treated with IGRT. Mean laryngeal dose was, respectively, 41.2 Gy and 22.8 Gy for the IMRT and IGRT technique (p < 0.001). The radiation dose to the middle and inferior pharyngeal muscles was also significantly reduced with the IGRT technique. Mean pharyngeal dose was, respectively, 52 Gy and 26 Gy for the IMRT and IGRT technique (p = 0.0001). Laryngeal sparing IGRT technique for head and neck cancer minimizes radiotherapy dose to the larynx and pharynx without sacrificing target coverage, even in the presence of neck lymph nodes.

Original languageEnglish (US)
Pages (from-to)283-286
Number of pages4
JournalOral Oncology
Volume46
Issue number4
DOIs
StatePublished - Apr 2010

Fingerprint

Image-Guided Radiotherapy
Head and Neck Neoplasms
Larynx
Pharyngeal Muscles
Radiation
Intensity-Modulated Radiotherapy
Pharynx
Neck
Radiotherapy
Lymph Nodes

Keywords

  • Head and neck cancer
  • IGRT
  • Laryngeal sparing

ASJC Scopus subject areas

  • Oncology
  • Oral Surgery
  • Cancer Research

Cite this

Nguyen, N. P., Ceizyk, M., Vos, P., Vinh-Hung, V., Davis, R., Desai, A., ... Smith-Raymond, L. (2010). Effectiveness of image-guided radiotherapy for laryngeal sparing in head and neck cancer. Oral Oncology, 46(4), 283-286. https://doi.org/10.1016/j.oraloncology.2010.01.010

Effectiveness of image-guided radiotherapy for laryngeal sparing in head and neck cancer. / Nguyen, Nam P.; Ceizyk, Misty; Vos, Paul; Vinh-Hung, Vincent; Davis, Rick; Desai, Anand; Abraham, Dave; Krafft, Shane P.; Jang, Siyoung; Watchman, Christopher J; Ewell, Lars; Hamilton, Russell J; Smith-Raymond, Lexie.

In: Oral Oncology, Vol. 46, No. 4, 04.2010, p. 283-286.

Research output: Contribution to journalArticle

Nguyen, NP, Ceizyk, M, Vos, P, Vinh-Hung, V, Davis, R, Desai, A, Abraham, D, Krafft, SP, Jang, S, Watchman, CJ, Ewell, L, Hamilton, RJ & Smith-Raymond, L 2010, 'Effectiveness of image-guided radiotherapy for laryngeal sparing in head and neck cancer', Oral Oncology, vol. 46, no. 4, pp. 283-286. https://doi.org/10.1016/j.oraloncology.2010.01.010
Nguyen, Nam P. ; Ceizyk, Misty ; Vos, Paul ; Vinh-Hung, Vincent ; Davis, Rick ; Desai, Anand ; Abraham, Dave ; Krafft, Shane P. ; Jang, Siyoung ; Watchman, Christopher J ; Ewell, Lars ; Hamilton, Russell J ; Smith-Raymond, Lexie. / Effectiveness of image-guided radiotherapy for laryngeal sparing in head and neck cancer. In: Oral Oncology. 2010 ; Vol. 46, No. 4. pp. 283-286.
@article{bbfb1061f4b04c9db48eb45c2dcab4a1,
title = "Effectiveness of image-guided radiotherapy for laryngeal sparing in head and neck cancer",
abstract = "We would like to compare the effectiveness of image-guided (IGRT) and intensity-modulated (IMRT) radiotherapy to spare the larynx in head and neck cancer patients. A retrospective review of 48 patients undergoing radiation for non-laryngeal and non-hypopharyngeal head and neck cancers. Mean laryngeal and hypopharyngeal dose was compared between 11 patients treated with IMRT and 37 patients treated with IGRT. Mean laryngeal dose was, respectively, 41.2 Gy and 22.8 Gy for the IMRT and IGRT technique (p < 0.001). The radiation dose to the middle and inferior pharyngeal muscles was also significantly reduced with the IGRT technique. Mean pharyngeal dose was, respectively, 52 Gy and 26 Gy for the IMRT and IGRT technique (p = 0.0001). Laryngeal sparing IGRT technique for head and neck cancer minimizes radiotherapy dose to the larynx and pharynx without sacrificing target coverage, even in the presence of neck lymph nodes.",
keywords = "Head and neck cancer, IGRT, Laryngeal sparing",
author = "Nguyen, {Nam P.} and Misty Ceizyk and Paul Vos and Vincent Vinh-Hung and Rick Davis and Anand Desai and Dave Abraham and Krafft, {Shane P.} and Siyoung Jang and Watchman, {Christopher J} and Lars Ewell and Hamilton, {Russell J} and Lexie Smith-Raymond",
year = "2010",
month = "4",
doi = "10.1016/j.oraloncology.2010.01.010",
language = "English (US)",
volume = "46",
pages = "283--286",
journal = "Oral Oncology",
issn = "1368-8375",
publisher = "Elsevier Limited",
number = "4",

}

TY - JOUR

T1 - Effectiveness of image-guided radiotherapy for laryngeal sparing in head and neck cancer

AU - Nguyen, Nam P.

AU - Ceizyk, Misty

AU - Vos, Paul

AU - Vinh-Hung, Vincent

AU - Davis, Rick

AU - Desai, Anand

AU - Abraham, Dave

AU - Krafft, Shane P.

AU - Jang, Siyoung

AU - Watchman, Christopher J

AU - Ewell, Lars

AU - Hamilton, Russell J

AU - Smith-Raymond, Lexie

PY - 2010/4

Y1 - 2010/4

N2 - We would like to compare the effectiveness of image-guided (IGRT) and intensity-modulated (IMRT) radiotherapy to spare the larynx in head and neck cancer patients. A retrospective review of 48 patients undergoing radiation for non-laryngeal and non-hypopharyngeal head and neck cancers. Mean laryngeal and hypopharyngeal dose was compared between 11 patients treated with IMRT and 37 patients treated with IGRT. Mean laryngeal dose was, respectively, 41.2 Gy and 22.8 Gy for the IMRT and IGRT technique (p < 0.001). The radiation dose to the middle and inferior pharyngeal muscles was also significantly reduced with the IGRT technique. Mean pharyngeal dose was, respectively, 52 Gy and 26 Gy for the IMRT and IGRT technique (p = 0.0001). Laryngeal sparing IGRT technique for head and neck cancer minimizes radiotherapy dose to the larynx and pharynx without sacrificing target coverage, even in the presence of neck lymph nodes.

AB - We would like to compare the effectiveness of image-guided (IGRT) and intensity-modulated (IMRT) radiotherapy to spare the larynx in head and neck cancer patients. A retrospective review of 48 patients undergoing radiation for non-laryngeal and non-hypopharyngeal head and neck cancers. Mean laryngeal and hypopharyngeal dose was compared between 11 patients treated with IMRT and 37 patients treated with IGRT. Mean laryngeal dose was, respectively, 41.2 Gy and 22.8 Gy for the IMRT and IGRT technique (p < 0.001). The radiation dose to the middle and inferior pharyngeal muscles was also significantly reduced with the IGRT technique. Mean pharyngeal dose was, respectively, 52 Gy and 26 Gy for the IMRT and IGRT technique (p = 0.0001). Laryngeal sparing IGRT technique for head and neck cancer minimizes radiotherapy dose to the larynx and pharynx without sacrificing target coverage, even in the presence of neck lymph nodes.

KW - Head and neck cancer

KW - IGRT

KW - Laryngeal sparing

UR - http://www.scopus.com/inward/record.url?scp=77949569228&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77949569228&partnerID=8YFLogxK

U2 - 10.1016/j.oraloncology.2010.01.010

DO - 10.1016/j.oraloncology.2010.01.010

M3 - Article

VL - 46

SP - 283

EP - 286

JO - Oral Oncology

JF - Oral Oncology

SN - 1368-8375

IS - 4

ER -