EFFEKTE EINER AKUTGABE VON TRANDOLAPRIL AUF DIE INSULINSTIMULIERTE GLUKOSEAUFNAHME IM ISOLIERTEN SKELETTMUSKEL DER FA/FA ZUCKER-RATTE

Translated title of the contribution: Effects of acute trandolapril treatment on insulin-stimulated glucose transport activity in skeletal muscle of obese Zucker rats

S. Jacob, Erik J Henriksen, H. J. Augustin, G. J. Dietze

Research output: Contribution to journalArticle

Abstract

Antihypertensive agents have various effects on glucose metabolism; beta-blockers and thiazides were shown to reduce insulin sensitivity, calcium channel blockers seem to be inert, and α1-blockers and ACE-inhibitors (AI) tend to improve insulin stimulated glucose uptake after acute and chronic administration. It is, however, not known whether this improvement is caused by an increase in (muscular) blood flow - as both agents cause vasodilation - or whether there is a more specific effect on glucose uptake. We therefore choose a model of isolated muscle to minimize the influence of blood flow; we used an animal model of insulin resistance - the obese Zucker (fa/fa) rat - to test whether acute (3 h) oral administration of the AI trandolapril (without SU-groups) has a direct effect on insulin-stimulated glucose transport activity in skeletal muscle. In vitro glucose transport activity in the epitrochlearis muscle was assessed by 2-deoxyglucose uptake in the absence or presence of insulin (2 mU/ml). Insulin-stimulated 2-deoxyglucose uptake was only ~ 50% as great in muscles from obese animals compared to lean (Fa/-) controls (p < 0.05), but was significantly (p < 0.05) improved by acute (+33%, p < 0.05) treatment with trandolapril. We conclude that the isolated epitrochlearis muscle from the obese Zucker rat is a suitable model for studying insulin resistance in skeletal muscle; that trandolapril significantly improves insulin-stimulated glucose transport activity in skeletal muscle in the obese Zucker rat after acute administration and that SH groups do not seem to play any role. Our data therefore support the hypothesis that the ACE inhibitors as a group can improve glucose disposal via a direct effect on the skeletal muscle glucose transport system.

Original languageGerman
Pages (from-to)237-239
Number of pages3
JournalNieren- und Hochdruckkrankheiten
Volume24
Issue number5
StatePublished - 1995
Externally publishedYes

Fingerprint

trandolapril
Zucker Rats
Skeletal Muscle
Insulin
Glucose
Angiotensin-Converting Enzyme Inhibitors
Insulin Resistance
Muscles
Deoxyglucose
Therapeutics
Thiazides
Calcium Channel Blockers

Keywords

  • acute effects
  • angiotensin converting enzyme inhibitor
  • epitrochlearis muscle
  • insulin resistance

ASJC Scopus subject areas

  • Internal Medicine
  • Nephrology

Cite this

EFFEKTE EINER AKUTGABE VON TRANDOLAPRIL AUF DIE INSULINSTIMULIERTE GLUKOSEAUFNAHME IM ISOLIERTEN SKELETTMUSKEL DER FA/FA ZUCKER-RATTE. / Jacob, S.; Henriksen, Erik J; Augustin, H. J.; Dietze, G. J.

In: Nieren- und Hochdruckkrankheiten, Vol. 24, No. 5, 1995, p. 237-239.

Research output: Contribution to journalArticle

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abstract = "Antihypertensive agents have various effects on glucose metabolism; beta-blockers and thiazides were shown to reduce insulin sensitivity, calcium channel blockers seem to be inert, and α1-blockers and ACE-inhibitors (AI) tend to improve insulin stimulated glucose uptake after acute and chronic administration. It is, however, not known whether this improvement is caused by an increase in (muscular) blood flow - as both agents cause vasodilation - or whether there is a more specific effect on glucose uptake. We therefore choose a model of isolated muscle to minimize the influence of blood flow; we used an animal model of insulin resistance - the obese Zucker (fa/fa) rat - to test whether acute (3 h) oral administration of the AI trandolapril (without SU-groups) has a direct effect on insulin-stimulated glucose transport activity in skeletal muscle. In vitro glucose transport activity in the epitrochlearis muscle was assessed by 2-deoxyglucose uptake in the absence or presence of insulin (2 mU/ml). Insulin-stimulated 2-deoxyglucose uptake was only ~ 50{\%} as great in muscles from obese animals compared to lean (Fa/-) controls (p < 0.05), but was significantly (p < 0.05) improved by acute (+33{\%}, p < 0.05) treatment with trandolapril. We conclude that the isolated epitrochlearis muscle from the obese Zucker rat is a suitable model for studying insulin resistance in skeletal muscle; that trandolapril significantly improves insulin-stimulated glucose transport activity in skeletal muscle in the obese Zucker rat after acute administration and that SH groups do not seem to play any role. Our data therefore support the hypothesis that the ACE inhibitors as a group can improve glucose disposal via a direct effect on the skeletal muscle glucose transport system.",
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