Abstract
It is clear that the properties of LTE make it a plausible mechanism for associative information storage at some synapses in the central nervous system. While many of the factors that regulate LTE's induction and expression have been discovered and a strong case is being developed for its role in learning and memory processes, until we understand more clearly the mechanisms underlying both the expression and maintenance of LTE, an understanding of its change with age will be difficult. Judging by the progress that has been made over the past several years in uncovering some of the molecular events that are critical for LTE's expression, one may be optimistic that answers will be forthcoming reasonably soon. Of particular importance to aging mammals, such answers may provide insights into why older organisms show faster forgetting. This may have a profound impact on therapeutic strategies for memory disorders in both normal and pathological conditions of aging.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 89-104 |
| Number of pages | 16 |
| Journal | Progress in Brain Research |
| Volume | 86 |
| State | Published - 1990 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Neuroscience(all)
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Effects of aging on the dynamics of information processing and synaptic weight changes in the mammalian hippocampus. / Barnes, Carol A.
In: Progress in Brain Research, Vol. 86, 1990, p. 89-104.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effects of aging on the dynamics of information processing and synaptic weight changes in the mammalian hippocampus
AU - Barnes, Carol A
PY - 1990
Y1 - 1990
N2 - It is clear that the properties of LTE make it a plausible mechanism for associative information storage at some synapses in the central nervous system. While many of the factors that regulate LTE's induction and expression have been discovered and a strong case is being developed for its role in learning and memory processes, until we understand more clearly the mechanisms underlying both the expression and maintenance of LTE, an understanding of its change with age will be difficult. Judging by the progress that has been made over the past several years in uncovering some of the molecular events that are critical for LTE's expression, one may be optimistic that answers will be forthcoming reasonably soon. Of particular importance to aging mammals, such answers may provide insights into why older organisms show faster forgetting. This may have a profound impact on therapeutic strategies for memory disorders in both normal and pathological conditions of aging.
AB - It is clear that the properties of LTE make it a plausible mechanism for associative information storage at some synapses in the central nervous system. While many of the factors that regulate LTE's induction and expression have been discovered and a strong case is being developed for its role in learning and memory processes, until we understand more clearly the mechanisms underlying both the expression and maintenance of LTE, an understanding of its change with age will be difficult. Judging by the progress that has been made over the past several years in uncovering some of the molecular events that are critical for LTE's expression, one may be optimistic that answers will be forthcoming reasonably soon. Of particular importance to aging mammals, such answers may provide insights into why older organisms show faster forgetting. This may have a profound impact on therapeutic strategies for memory disorders in both normal and pathological conditions of aging.
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M3 - Article
C2 - 1965057
AN - SCOPUS:0025677235
VL - 86
SP - 89
EP - 104
JO - Progress in Brain Research
JF - Progress in Brain Research
SN - 0079-6123
ER -