Effects of aging on the dynamics of information processing and synaptic weight changes in the mammalian hippocampus

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29 Citations (Scopus)

Abstract

It is clear that the properties of LTE make it a plausible mechanism for associative information storage at some synapses in the central nervous system. While many of the factors that regulate LTE's induction and expression have been discovered and a strong case is being developed for its role in learning and memory processes, until we understand more clearly the mechanisms underlying both the expression and maintenance of LTE, an understanding of its change with age will be difficult. Judging by the progress that has been made over the past several years in uncovering some of the molecular events that are critical for LTE's expression, one may be optimistic that answers will be forthcoming reasonably soon. Of particular importance to aging mammals, such answers may provide insights into why older organisms show faster forgetting. This may have a profound impact on therapeutic strategies for memory disorders in both normal and pathological conditions of aging.

Original languageEnglish (US)
Pages (from-to)89-104
Number of pages16
JournalProgress in Brain Research
Volume86
StatePublished - 1990
Externally publishedYes

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Information Storage and Retrieval
Memory Disorders
Automatic Data Processing
Synapses
Mammals
Hippocampus
Central Nervous System
Maintenance
Learning
Weights and Measures
Therapeutics

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

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abstract = "It is clear that the properties of LTE make it a plausible mechanism for associative information storage at some synapses in the central nervous system. While many of the factors that regulate LTE's induction and expression have been discovered and a strong case is being developed for its role in learning and memory processes, until we understand more clearly the mechanisms underlying both the expression and maintenance of LTE, an understanding of its change with age will be difficult. Judging by the progress that has been made over the past several years in uncovering some of the molecular events that are critical for LTE's expression, one may be optimistic that answers will be forthcoming reasonably soon. Of particular importance to aging mammals, such answers may provide insights into why older organisms show faster forgetting. This may have a profound impact on therapeutic strategies for memory disorders in both normal and pathological conditions of aging.",
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AB - It is clear that the properties of LTE make it a plausible mechanism for associative information storage at some synapses in the central nervous system. While many of the factors that regulate LTE's induction and expression have been discovered and a strong case is being developed for its role in learning and memory processes, until we understand more clearly the mechanisms underlying both the expression and maintenance of LTE, an understanding of its change with age will be difficult. Judging by the progress that has been made over the past several years in uncovering some of the molecular events that are critical for LTE's expression, one may be optimistic that answers will be forthcoming reasonably soon. Of particular importance to aging mammals, such answers may provide insights into why older organisms show faster forgetting. This may have a profound impact on therapeutic strategies for memory disorders in both normal and pathological conditions of aging.

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