On the basis of a diffusional model and certain wellknown physical‐chemical relationships, equations were derived which describe the relative biological activities of alkyl homologs. These equations were applied to the goldfish turnover time produced by both saturated solutions and equimolar solutions of eight n‐alkyl esters of p‐aminobenzoic acid. The results show that the apparant parabolic structure‐activity curve can be described quite well by a simple solubility‐limited diffusional model.
- Chain length effect—alkyl p‐aminobenzoate‐induced narcosis in goldfish, solubility‐limited diffusional model, equations
- Goldfish turnover—chain‐length effect of alkyl p‐aminobenzoates, diffusion model, equations
- p‐Aminobenzoic acid ester‐induced narcosis in goldfish—chain length effect, solubility‐limited diffusional model, equations
ASJC Scopus subject areas
- Pharmaceutical Science