Effects of anti-Ia sera on mitogenic responses: II. Differential expression of the Ia marker on phytohemagglutininand concanavalin A-reactive T cells*

John E. Niederhuber, Jeffrey A. Frelinger, Mary S. Dine, Patricia Shoffner, Elizabeth Dugan, Donald C. Shreffler

Research output: Contribution to journalArticle

54 Scopus citations

Abstract

Genes mapping in the I region of the H-2 complex control a system of lymphocyte alloantigens (Ia) which are expressed on a subpopulation of T cells and on most B cells. Specific anti-Ia serum in the presence of rabbit complement removed the splenic T-cell subpepulation responsive to Con-A, but did not affect the response to phytohemagglutinin (PHA) or Leucoagglutinin. Antibodies specific for Ia, H-2K, or H-2D membrane antigens were used without complement to pretreat spleen cells. These antibody pretreated cells responded normally to Con-A and PHA.

Original languageEnglish (US)
Pages (from-to)372-381
Number of pages10
JournalJournal of Experimental Medicine
Volume143
Issue number2
DOIs
StatePublished - Feb 1 1976

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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