Effects of anti Ia sera on mitogenic responses. II. Differential expression of the Ia marker on phytohemagglutinin- and concanavalin A reactive T cells

J. E. Niederhuber, Jeffrey A Frelinger, M. S. Dine, P. Shoffner, E. Dugan, D. C. Shreffler

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

Genes mapping in the I region of the H 2 complex control a system of lymphocyte alloantigens (Ia) which are expressed on a subpopulation of T cells and on most B cells. Specific anti Ia serum in the presence of rabbit complement removed the splenic T cell subpopulation responsive to Con A, but did not affect the response to phytohemagglutinin (PHA) or Leucoagglutinin. Antibodies specific for Ia, H 2K, or H 2D membrane antigens were used without complement to pretreat spleen cells. These antibody pretreated cells responded normally to Con A and PHA.

Original languageEnglish (US)
Pages (from-to)372-381
Number of pages10
JournalJournal of Experimental Medicine
Volume143
Issue number2
DOIs
StatePublished - 1976
Externally publishedYes

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Phytohemagglutinins
Concanavalin A
T-Lymphocytes
Isoantigens
Antibodies
Chromosome Mapping
Serum
B-Lymphocytes
Spleen
Lymphocytes
Rabbits
Antigens
Membranes

ASJC Scopus subject areas

  • Immunology

Cite this

Effects of anti Ia sera on mitogenic responses. II. Differential expression of the Ia marker on phytohemagglutinin- and concanavalin A reactive T cells. / Niederhuber, J. E.; Frelinger, Jeffrey A; Dine, M. S.; Shoffner, P.; Dugan, E.; Shreffler, D. C.

In: Journal of Experimental Medicine, Vol. 143, No. 2, 1976, p. 372-381.

Research output: Contribution to journalArticle

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