Effects of anti Ia sera on mitogenic responses. III. Mapping the genes controlling the expression of Ia determinants on concanavalin A reactive cells to the I-J subregion of the H-2 gene complex

Jeffrey A Frelinger, J. E. Niederhuber, D. C. Shreffler

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

It was shown that the Ia determinants expressed on nylon wool purified T lymphocytes reactive to concanavalin A (Con A) in serum free media are coded in a single I subregion of the H 2 gene complex. This region, I J, is defined by two pairs of intra H 2 recombinant haplotypes: H 2(t3), H 2(t4) and H 2(i3), H 2(i5), carried by B10.HTT, B10.S(9R), B10.A(3R), and B10.A(5R), respectively. No activity against Con A reactive T cells has been detected in any antiserum that was produced in strain combinations which shared a common I J region. This suggests that Ia antigens expressed on Con A reactive T cells are restricted to the I J subregion.

Original languageEnglish (US)
Pages (from-to)1141-1146
Number of pages6
JournalJournal of Experimental Medicine
Volume144
Issue number4
StatePublished - 1976
Externally publishedYes

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Concanavalin A
T-Lymphocytes
Gene Expression
Serum
Genes
Wool
Histocompatibility Antigens Class II
Nylons
Serum-Free Culture Media
Haplotypes
Immune Sera

ASJC Scopus subject areas

  • Immunology

Cite this

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abstract = "It was shown that the Ia determinants expressed on nylon wool purified T lymphocytes reactive to concanavalin A (Con A) in serum free media are coded in a single I subregion of the H 2 gene complex. This region, I J, is defined by two pairs of intra H 2 recombinant haplotypes: H 2(t3), H 2(t4) and H 2(i3), H 2(i5), carried by B10.HTT, B10.S(9R), B10.A(3R), and B10.A(5R), respectively. No activity against Con A reactive T cells has been detected in any antiserum that was produced in strain combinations which shared a common I J region. This suggests that Ia antigens expressed on Con A reactive T cells are restricted to the I J subregion.",
author = "Frelinger, {Jeffrey A} and Niederhuber, {J. E.} and Shreffler, {D. C.}",
year = "1976",
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T1 - Effects of anti Ia sera on mitogenic responses. III. Mapping the genes controlling the expression of Ia determinants on concanavalin A reactive cells to the I-J subregion of the H-2 gene complex

AU - Frelinger, Jeffrey A

AU - Niederhuber, J. E.

AU - Shreffler, D. C.

PY - 1976

Y1 - 1976

N2 - It was shown that the Ia determinants expressed on nylon wool purified T lymphocytes reactive to concanavalin A (Con A) in serum free media are coded in a single I subregion of the H 2 gene complex. This region, I J, is defined by two pairs of intra H 2 recombinant haplotypes: H 2(t3), H 2(t4) and H 2(i3), H 2(i5), carried by B10.HTT, B10.S(9R), B10.A(3R), and B10.A(5R), respectively. No activity against Con A reactive T cells has been detected in any antiserum that was produced in strain combinations which shared a common I J region. This suggests that Ia antigens expressed on Con A reactive T cells are restricted to the I J subregion.

AB - It was shown that the Ia determinants expressed on nylon wool purified T lymphocytes reactive to concanavalin A (Con A) in serum free media are coded in a single I subregion of the H 2 gene complex. This region, I J, is defined by two pairs of intra H 2 recombinant haplotypes: H 2(t3), H 2(t4) and H 2(i3), H 2(i5), carried by B10.HTT, B10.S(9R), B10.A(3R), and B10.A(5R), respectively. No activity against Con A reactive T cells has been detected in any antiserum that was produced in strain combinations which shared a common I J region. This suggests that Ia antigens expressed on Con A reactive T cells are restricted to the I J subregion.

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