Effects of anti Ia serum on mitogenic responses. I. Inhibition of the proliferative response to B cell mitogen, LPS by specific anti Ia sera

J. E. Niederhuber, J. A. Frelinger, E. Dugan, A. Coutinho, D. C. Shreffler

Research output: Contribution to journalArticle

56 Scopus citations

Abstract

Specific anti Ia serum in combination with rabbit complement removed the B lymphocyte population normally responsive to LPS mitogenic stimulation. Significant inhibition of this proliferative response was also obtained by brief periods of cell pretreatment with anti Ia antibodies, but not with specific anti H 2K antibodies. The population of splenic B cells resistant to anti Thy 1.2 serum and complement was blocked in a very similar manner by anti Ia serum, but not by anti H 2 serum.

Original languageEnglish (US)
Pages (from-to)1672-1676
Number of pages5
JournalJournal of Immunology
Volume115
Issue number6
StatePublished - Dec 1 1975
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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