Effects of caffeoylquinic acid derivatives and C-flavonoid from Lychnophora ericoides on in vitro inflammatory mediator production

Michel David Dos Santos, Guanjie Chen, Maria Camila Almeida, Denis Melo Soares, Glória Emília Petto De Souzaa, Norberto Peporine Lopes, R. Clark Lantz

Research output: Contribution to journalArticlepeer-review

39 Scopus citations

Abstract

In this study we aimed at evaluating the effect of the major polar constituents of the medicinal plant Lychnophora ericoides on the production of inflammatory mediators produced by LPS-stimulated U-937 cells. The 6,8-di-C-β-glucosylapigenin (vicenin-2) presented no effect on tumor necrosis factor (TNF)-α production, but inhibited, in a dose-dependent manner, the production of prostaglandin (PG) E2 without altering the expression of cyclooxygenase (COX) -2 protein. 3,5-Dicaffeoylquinic acid and 4,5-dicaffeoylquinic acid, at lower concentrations, had small but significant effects on reducing PGE2 levels; at higher doses these compounds stimulated PGE2 and also TNF-α production by the cells. All the caffeoylquinic acid derivatives, in a dose-dependent fashion, were able to inhibit monocyte chemoattractant protein-3 synthesis/release, with 4,5-DCQ being the most potent at the highest tested concentration. These results add important information on the effects of plant natural polyphenols, namely vicenin-2 and caffeoylquinic acid derivatives, on the production of inflammatory mediators by cultured cells.

Original languageEnglish (US)
Pages (from-to)733-740
Number of pages8
JournalNatural Product Communications
Volume5
Issue number5
StatePublished - 2010

Keywords

  • Caffeoylquinic acids
  • Cytokines
  • Lychnophora ericoides
  • PGE
  • Polyphenols
  • U-937
  • Vicenin-2

ASJC Scopus subject areas

  • Pharmacology
  • Plant Science
  • Drug Discovery
  • Complementary and alternative medicine

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