Effects of chronic β-carotene supplementation on vitamin K status in adults

L. M. Canfield, J. J. Corrigan, P. M. Plezia, M. Jeter, S. Sayers, David S Alberts

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Abstract

Plasma vitamin K concentrations and prothrombin coagulation activity were determined in 26 normal adults who had received daily β-carotene supplementation (0, 15, 30, or 60 mg) for six months. Neither plasma vitamin K nor coagulation activity were significantly decreased at any supplementation level. Thus, chronic β-carotene supplementation, even at high daily doses, is not expected to result in clinical vitamin K deficiency. The data suggest separate mechanisms for intestinal absorption of β-carotene and vitamin K.

Original languageEnglish (US)
Pages (from-to)263-269
Number of pages7
JournalNutrition and Cancer
Volume13
Issue number4
Publication statusPublished - 1990

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ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Oncology
  • Food Science

Cite this

Canfield, L. M., Corrigan, J. J., Plezia, P. M., Jeter, M., Sayers, S., & Alberts, D. S. (1990). Effects of chronic β-carotene supplementation on vitamin K status in adults. Nutrition and Cancer, 13(4), 263-269.