Abstract
The authors conducted a 2-year (1989-1991) community-based longitudinal study in a shantytown in Lima, Peru, to examine the effect of Cryptosporidium parvum infection on child growth during the year following the onset of infection. A cohort of children, aged 0-3 months at recruitment, was followed monthly for anthropometrics, weekly for stool samples, and daily for diarrheal status. Data from 185 children in the cohort permitted a comparison of growth in C. parvum-infected and noninfected children. The analyses fitted smooth, flexible curves with a linear random-effects model to estimate growth differences between C. parvum-infected and noninfected children. Children infected with C. parvum experienced growth faltering, both in weight and in height, for several months after the onset of infection, followed by a period of catch-up growth. Younger children took longer to catch up in weight than did older children. Catch-up growth, however, did not occur in children infected between ages 0 and 5 months. These children did not catch up in height, and one year after infection they exhibited an average deficit of 0.95 cm (95% confidence interval (CI) 0.38-1.53) relative to noninfected children of similar age. Stunted children who became infected also did not catch up in either weight or height, and one year after infection they exhibited a height deficit of 1.05 cm (95% CI 0,46-1;66) relative to noninfected, stunted children of similar age. These results indicate that Cryptosporidium parvum has a lasting adverse effect on linear (height) growth, especially when acquired during infancy and when children are stunted before they become infected.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 497-506 |
| Number of pages | 10 |
| Journal | American Journal of Epidemiology |
| Volume | 148 |
| Issue number | 5 |
| State | Published - Sep 1 1998 |
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Keywords
- Cryptosporidium parvum
- Diarrhea, infantile
- Growth disorders
- Infection
- Longitudinal studies
- Nutrition disorders
- Smoothing splines
- Statistics
ASJC Scopus subject areas
- Epidemiology
Cite this
Effects of Cryptosporidium parvum infection in Peruvian children : Growth faltering and subsequent catch-up growth. / Checkley, William; Epstein, Leonardo D.; Gilman, Robert H.; Black, Robert E.; Cabrera, Lilia; Sterling, Charles R.
In: American Journal of Epidemiology, Vol. 148, No. 5, 01.09.1998, p. 497-506.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effects of Cryptosporidium parvum infection in Peruvian children
T2 - Growth faltering and subsequent catch-up growth
AU - Checkley, William
AU - Epstein, Leonardo D.
AU - Gilman, Robert H.
AU - Black, Robert E.
AU - Cabrera, Lilia
AU - Sterling, Charles R
PY - 1998/9/1
Y1 - 1998/9/1
N2 - The authors conducted a 2-year (1989-1991) community-based longitudinal study in a shantytown in Lima, Peru, to examine the effect of Cryptosporidium parvum infection on child growth during the year following the onset of infection. A cohort of children, aged 0-3 months at recruitment, was followed monthly for anthropometrics, weekly for stool samples, and daily for diarrheal status. Data from 185 children in the cohort permitted a comparison of growth in C. parvum-infected and noninfected children. The analyses fitted smooth, flexible curves with a linear random-effects model to estimate growth differences between C. parvum-infected and noninfected children. Children infected with C. parvum experienced growth faltering, both in weight and in height, for several months after the onset of infection, followed by a period of catch-up growth. Younger children took longer to catch up in weight than did older children. Catch-up growth, however, did not occur in children infected between ages 0 and 5 months. These children did not catch up in height, and one year after infection they exhibited an average deficit of 0.95 cm (95% confidence interval (CI) 0.38-1.53) relative to noninfected children of similar age. Stunted children who became infected also did not catch up in either weight or height, and one year after infection they exhibited a height deficit of 1.05 cm (95% CI 0,46-1;66) relative to noninfected, stunted children of similar age. These results indicate that Cryptosporidium parvum has a lasting adverse effect on linear (height) growth, especially when acquired during infancy and when children are stunted before they become infected.
AB - The authors conducted a 2-year (1989-1991) community-based longitudinal study in a shantytown in Lima, Peru, to examine the effect of Cryptosporidium parvum infection on child growth during the year following the onset of infection. A cohort of children, aged 0-3 months at recruitment, was followed monthly for anthropometrics, weekly for stool samples, and daily for diarrheal status. Data from 185 children in the cohort permitted a comparison of growth in C. parvum-infected and noninfected children. The analyses fitted smooth, flexible curves with a linear random-effects model to estimate growth differences between C. parvum-infected and noninfected children. Children infected with C. parvum experienced growth faltering, both in weight and in height, for several months after the onset of infection, followed by a period of catch-up growth. Younger children took longer to catch up in weight than did older children. Catch-up growth, however, did not occur in children infected between ages 0 and 5 months. These children did not catch up in height, and one year after infection they exhibited an average deficit of 0.95 cm (95% confidence interval (CI) 0.38-1.53) relative to noninfected children of similar age. Stunted children who became infected also did not catch up in either weight or height, and one year after infection they exhibited a height deficit of 1.05 cm (95% CI 0,46-1;66) relative to noninfected, stunted children of similar age. These results indicate that Cryptosporidium parvum has a lasting adverse effect on linear (height) growth, especially when acquired during infancy and when children are stunted before they become infected.
KW - Cryptosporidium parvum
KW - Diarrhea, infantile
KW - Growth disorders
KW - Infection
KW - Longitudinal studies
KW - Nutrition disorders
KW - Smoothing splines
KW - Statistics
UR - http://www.scopus.com/inward/record.url?scp=0032167671&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032167671&partnerID=8YFLogxK
M3 - Article
C2 - 9737562
AN - SCOPUS:0032167671
VL - 148
SP - 497
EP - 506
JO - American Journal of Epidemiology
JF - American Journal of Epidemiology
SN - 0002-9262
IS - 5
ER -