Effects of Cryptosporidium parvum infection in Peruvian children: Growth faltering and subsequent catch-up growth

William Checkley, Leonardo D. Epstein, Robert H. Gilman, Robert E. Black, Lilia Cabrera, Charles R Sterling

Research output: Contribution to journalArticle

203 Citations (Scopus)

Abstract

The authors conducted a 2-year (1989-1991) community-based longitudinal study in a shantytown in Lima, Peru, to examine the effect of Cryptosporidium parvum infection on child growth during the year following the onset of infection. A cohort of children, aged 0-3 months at recruitment, was followed monthly for anthropometrics, weekly for stool samples, and daily for diarrheal status. Data from 185 children in the cohort permitted a comparison of growth in C. parvum-infected and noninfected children. The analyses fitted smooth, flexible curves with a linear random-effects model to estimate growth differences between C. parvum-infected and noninfected children. Children infected with C. parvum experienced growth faltering, both in weight and in height, for several months after the onset of infection, followed by a period of catch-up growth. Younger children took longer to catch up in weight than did older children. Catch-up growth, however, did not occur in children infected between ages 0 and 5 months. These children did not catch up in height, and one year after infection they exhibited an average deficit of 0.95 cm (95% confidence interval (CI) 0.38-1.53) relative to noninfected children of similar age. Stunted children who became infected also did not catch up in either weight or height, and one year after infection they exhibited a height deficit of 1.05 cm (95% CI 0,46-1;66) relative to noninfected, stunted children of similar age. These results indicate that Cryptosporidium parvum has a lasting adverse effect on linear (height) growth, especially when acquired during infancy and when children are stunted before they become infected.

Original languageEnglish (US)
Pages (from-to)497-506
Number of pages10
JournalAmerican Journal of Epidemiology
Volume148
Issue number5
StatePublished - Sep 1 1998

Fingerprint

Cryptosporidium parvum
Growth
Infection
Weights and Measures
Confidence Intervals
Peru

Keywords

  • Cryptosporidium parvum
  • Diarrhea, infantile
  • Growth disorders
  • Infection
  • Longitudinal studies
  • Nutrition disorders
  • Smoothing splines
  • Statistics

ASJC Scopus subject areas

  • Epidemiology

Cite this

Effects of Cryptosporidium parvum infection in Peruvian children : Growth faltering and subsequent catch-up growth. / Checkley, William; Epstein, Leonardo D.; Gilman, Robert H.; Black, Robert E.; Cabrera, Lilia; Sterling, Charles R.

In: American Journal of Epidemiology, Vol. 148, No. 5, 01.09.1998, p. 497-506.

Research output: Contribution to journalArticle

Checkley, William ; Epstein, Leonardo D. ; Gilman, Robert H. ; Black, Robert E. ; Cabrera, Lilia ; Sterling, Charles R. / Effects of Cryptosporidium parvum infection in Peruvian children : Growth faltering and subsequent catch-up growth. In: American Journal of Epidemiology. 1998 ; Vol. 148, No. 5. pp. 497-506.
@article{a4358c74ad3347c3b4e25fef4cf4c51b,
title = "Effects of Cryptosporidium parvum infection in Peruvian children: Growth faltering and subsequent catch-up growth",
abstract = "The authors conducted a 2-year (1989-1991) community-based longitudinal study in a shantytown in Lima, Peru, to examine the effect of Cryptosporidium parvum infection on child growth during the year following the onset of infection. A cohort of children, aged 0-3 months at recruitment, was followed monthly for anthropometrics, weekly for stool samples, and daily for diarrheal status. Data from 185 children in the cohort permitted a comparison of growth in C. parvum-infected and noninfected children. The analyses fitted smooth, flexible curves with a linear random-effects model to estimate growth differences between C. parvum-infected and noninfected children. Children infected with C. parvum experienced growth faltering, both in weight and in height, for several months after the onset of infection, followed by a period of catch-up growth. Younger children took longer to catch up in weight than did older children. Catch-up growth, however, did not occur in children infected between ages 0 and 5 months. These children did not catch up in height, and one year after infection they exhibited an average deficit of 0.95 cm (95{\%} confidence interval (CI) 0.38-1.53) relative to noninfected children of similar age. Stunted children who became infected also did not catch up in either weight or height, and one year after infection they exhibited a height deficit of 1.05 cm (95{\%} CI 0,46-1;66) relative to noninfected, stunted children of similar age. These results indicate that Cryptosporidium parvum has a lasting adverse effect on linear (height) growth, especially when acquired during infancy and when children are stunted before they become infected.",
keywords = "Cryptosporidium parvum, Diarrhea, infantile, Growth disorders, Infection, Longitudinal studies, Nutrition disorders, Smoothing splines, Statistics",
author = "William Checkley and Epstein, {Leonardo D.} and Gilman, {Robert H.} and Black, {Robert E.} and Lilia Cabrera and Sterling, {Charles R}",
year = "1998",
month = "9",
day = "1",
language = "English (US)",
volume = "148",
pages = "497--506",
journal = "American Journal of Epidemiology",
issn = "0002-9262",
publisher = "Oxford University Press",
number = "5",

}

TY - JOUR

T1 - Effects of Cryptosporidium parvum infection in Peruvian children

T2 - Growth faltering and subsequent catch-up growth

AU - Checkley, William

AU - Epstein, Leonardo D.

AU - Gilman, Robert H.

AU - Black, Robert E.

AU - Cabrera, Lilia

AU - Sterling, Charles R

PY - 1998/9/1

Y1 - 1998/9/1

N2 - The authors conducted a 2-year (1989-1991) community-based longitudinal study in a shantytown in Lima, Peru, to examine the effect of Cryptosporidium parvum infection on child growth during the year following the onset of infection. A cohort of children, aged 0-3 months at recruitment, was followed monthly for anthropometrics, weekly for stool samples, and daily for diarrheal status. Data from 185 children in the cohort permitted a comparison of growth in C. parvum-infected and noninfected children. The analyses fitted smooth, flexible curves with a linear random-effects model to estimate growth differences between C. parvum-infected and noninfected children. Children infected with C. parvum experienced growth faltering, both in weight and in height, for several months after the onset of infection, followed by a period of catch-up growth. Younger children took longer to catch up in weight than did older children. Catch-up growth, however, did not occur in children infected between ages 0 and 5 months. These children did not catch up in height, and one year after infection they exhibited an average deficit of 0.95 cm (95% confidence interval (CI) 0.38-1.53) relative to noninfected children of similar age. Stunted children who became infected also did not catch up in either weight or height, and one year after infection they exhibited a height deficit of 1.05 cm (95% CI 0,46-1;66) relative to noninfected, stunted children of similar age. These results indicate that Cryptosporidium parvum has a lasting adverse effect on linear (height) growth, especially when acquired during infancy and when children are stunted before they become infected.

AB - The authors conducted a 2-year (1989-1991) community-based longitudinal study in a shantytown in Lima, Peru, to examine the effect of Cryptosporidium parvum infection on child growth during the year following the onset of infection. A cohort of children, aged 0-3 months at recruitment, was followed monthly for anthropometrics, weekly for stool samples, and daily for diarrheal status. Data from 185 children in the cohort permitted a comparison of growth in C. parvum-infected and noninfected children. The analyses fitted smooth, flexible curves with a linear random-effects model to estimate growth differences between C. parvum-infected and noninfected children. Children infected with C. parvum experienced growth faltering, both in weight and in height, for several months after the onset of infection, followed by a period of catch-up growth. Younger children took longer to catch up in weight than did older children. Catch-up growth, however, did not occur in children infected between ages 0 and 5 months. These children did not catch up in height, and one year after infection they exhibited an average deficit of 0.95 cm (95% confidence interval (CI) 0.38-1.53) relative to noninfected children of similar age. Stunted children who became infected also did not catch up in either weight or height, and one year after infection they exhibited a height deficit of 1.05 cm (95% CI 0,46-1;66) relative to noninfected, stunted children of similar age. These results indicate that Cryptosporidium parvum has a lasting adverse effect on linear (height) growth, especially when acquired during infancy and when children are stunted before they become infected.

KW - Cryptosporidium parvum

KW - Diarrhea, infantile

KW - Growth disorders

KW - Infection

KW - Longitudinal studies

KW - Nutrition disorders

KW - Smoothing splines

KW - Statistics

UR - http://www.scopus.com/inward/record.url?scp=0032167671&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032167671&partnerID=8YFLogxK

M3 - Article

C2 - 9737562

AN - SCOPUS:0032167671

VL - 148

SP - 497

EP - 506

JO - American Journal of Epidemiology

JF - American Journal of Epidemiology

SN - 0002-9262

IS - 5

ER -