Effects of cytotoxic and immunosuppressive agents on the immune system

G. P. Bodey, Evan M Hersh, M. Valdivieso, R. Feid, V. Rodriguez

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18 Scopus citations

Abstract

Most chemotherapeutic agents are myelosuppressive and immunosuppressive. Consequently their use greatly increases a patient's susceptibility to infection. Neutropenia creates greater risk than lymphopenia and is a particular problem in patients with acute leukemia who are treated with combination chemotherapy. Chemotherapy is less immunosuppressive is given in short intensive courses rather than continuously. Continuous therapy causes severe depression of antibody production and inhibition of delayed hypersensitivity reaction.

Original languageEnglish (US)
Pages (from-to)67-74
Number of pages8
JournalPostgraduate Medicine
Volume58
Issue number7
Publication statusPublished - 1975
Externally publishedYes

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ASJC Scopus subject areas

  • Medicine(all)

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Bodey, G. P., Hersh, E. M., Valdivieso, M., Feid, R., & Rodriguez, V. (1975). Effects of cytotoxic and immunosuppressive agents on the immune system. Postgraduate Medicine, 58(7), 67-74.