Effects of dietary retinyl palmitate and selenium on tumoricidal capacity of macrophages in mice undergoing tumor promotion

Ronald R Watson, Satoru Moriguchi, Helen L. Gensler

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Dietary retinyl palmitate was administered for 22-30 weeks in CD-1 mice which had been initiated with 0.15 μmol of 7,12-dimethylbenz[a]-anthracene (DMBA) and promoted with 8 nmol of 12-O-tetradecanoylphorbol-13-acetate (TPA) twice weekly thereafter. This treatment resulted in a dose response in both the tumoricidal capacity of a selected number of isolated peritoneal macrophages (PM) and in skin tumor prevention. At 350 I.U./g of diet, retinyl palmitate (RP) also resulted in a 3-fold increase in the number of DM. RP significantly increased the total capacity of macrophage host defenses by increasing the number and individual capacity for cytotoxicity. Selenium (Se), at 2 parts/million in the drinking water, did not enhance PM tumoricidal capacity, although it did result in 60% reduction of mouse tumor burden.

Original languageEnglish (US)
Pages (from-to)181-187
Number of pages7
JournalCancer Letters
Volume36
Issue number2
DOIs
StatePublished - 1987

Fingerprint

Selenium
Macrophages
Peritoneal Macrophages
Neoplasms
9,10-Dimethyl-1,2-benzanthracene
Tetradecanoylphorbol Acetate
Tumor Burden
Drinking Water
Diet
Skin
retinol palmitate

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Biology
  • Oncology

Cite this

Effects of dietary retinyl palmitate and selenium on tumoricidal capacity of macrophages in mice undergoing tumor promotion. / Watson, Ronald R; Moriguchi, Satoru; Gensler, Helen L.

In: Cancer Letters, Vol. 36, No. 2, 1987, p. 181-187.

Research output: Contribution to journalArticle

@article{3075d972ef7e4351ae0e3deec6988bda,
title = "Effects of dietary retinyl palmitate and selenium on tumoricidal capacity of macrophages in mice undergoing tumor promotion",
abstract = "Dietary retinyl palmitate was administered for 22-30 weeks in CD-1 mice which had been initiated with 0.15 μmol of 7,12-dimethylbenz[a]-anthracene (DMBA) and promoted with 8 nmol of 12-O-tetradecanoylphorbol-13-acetate (TPA) twice weekly thereafter. This treatment resulted in a dose response in both the tumoricidal capacity of a selected number of isolated peritoneal macrophages (PM) and in skin tumor prevention. At 350 I.U./g of diet, retinyl palmitate (RP) also resulted in a 3-fold increase in the number of DM. RP significantly increased the total capacity of macrophage host defenses by increasing the number and individual capacity for cytotoxicity. Selenium (Se), at 2 parts/million in the drinking water, did not enhance PM tumoricidal capacity, although it did result in 60{\%} reduction of mouse tumor burden.",
author = "Watson, {Ronald R} and Satoru Moriguchi and Gensler, {Helen L.}",
year = "1987",
doi = "10.1016/0304-3835(87)90089-9",
language = "English (US)",
volume = "36",
pages = "181--187",
journal = "Cancer Letters",
issn = "0304-3835",
publisher = "Elsevier Ireland Ltd",
number = "2",

}

TY - JOUR

T1 - Effects of dietary retinyl palmitate and selenium on tumoricidal capacity of macrophages in mice undergoing tumor promotion

AU - Watson, Ronald R

AU - Moriguchi, Satoru

AU - Gensler, Helen L.

PY - 1987

Y1 - 1987

N2 - Dietary retinyl palmitate was administered for 22-30 weeks in CD-1 mice which had been initiated with 0.15 μmol of 7,12-dimethylbenz[a]-anthracene (DMBA) and promoted with 8 nmol of 12-O-tetradecanoylphorbol-13-acetate (TPA) twice weekly thereafter. This treatment resulted in a dose response in both the tumoricidal capacity of a selected number of isolated peritoneal macrophages (PM) and in skin tumor prevention. At 350 I.U./g of diet, retinyl palmitate (RP) also resulted in a 3-fold increase in the number of DM. RP significantly increased the total capacity of macrophage host defenses by increasing the number and individual capacity for cytotoxicity. Selenium (Se), at 2 parts/million in the drinking water, did not enhance PM tumoricidal capacity, although it did result in 60% reduction of mouse tumor burden.

AB - Dietary retinyl palmitate was administered for 22-30 weeks in CD-1 mice which had been initiated with 0.15 μmol of 7,12-dimethylbenz[a]-anthracene (DMBA) and promoted with 8 nmol of 12-O-tetradecanoylphorbol-13-acetate (TPA) twice weekly thereafter. This treatment resulted in a dose response in both the tumoricidal capacity of a selected number of isolated peritoneal macrophages (PM) and in skin tumor prevention. At 350 I.U./g of diet, retinyl palmitate (RP) also resulted in a 3-fold increase in the number of DM. RP significantly increased the total capacity of macrophage host defenses by increasing the number and individual capacity for cytotoxicity. Selenium (Se), at 2 parts/million in the drinking water, did not enhance PM tumoricidal capacity, although it did result in 60% reduction of mouse tumor burden.

UR - http://www.scopus.com/inward/record.url?scp=0023245049&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023245049&partnerID=8YFLogxK

U2 - 10.1016/0304-3835(87)90089-9

DO - 10.1016/0304-3835(87)90089-9

M3 - Article

C2 - 3621150

AN - SCOPUS:0023245049

VL - 36

SP - 181

EP - 187

JO - Cancer Letters

JF - Cancer Letters

SN - 0304-3835

IS - 2

ER -