Effects of grayscale window/level parameters on breast lesion detectability

Jeffrey P. Johnson, John Nafziger, Elizabeth A Krupinski, Jeffrey Lubin, Hans Roehrig

Research output: Chapter in Book/Report/Conference proceedingConference contribution

18 Scopus citations

Abstract

The detectability of low-contrast lesions in medical images can be affected significantly by the choice of grayscale window width and level (W/L) for electronic display. Our objective was to measure the effects of various W/L conditions on lesion detectability in simulated and real mammographic images, and then correlate observer performance with predictions of detection thresholds derived from a visual discrimination model (VDM). In the first experiment, detection thresholds were measured in 2AFC trials for five W/L conditions applied to simulated mammographic backgrounds and lesions (i.e., Gaussian "masses" and blurred-disk "microcalcification clusters") using nonmedical observers. In the second experiment, the detectability of real microcalcification clusters in digitized mammograms was evaluated for three W/L conditions in an ROC observer study with mammographers. For the simulated images, there was generally good agreement between model and experimental thresholds and their variations across W/L conditions. Both experimental and model results showed significant reductions in thresholds when W/L processing was applied locally near the lesion. ROC results with digitized mammograms read by radiologists, however, failed to show enhanced detection of microcalcifications using a localized W/L frame, probably due to the nonuniform appearance of parenchymal tissue across the image.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
EditorsP. Chakraborty, E.A. Krupinski
Pages462-473
Number of pages12
Volume5034
DOIs
Publication statusPublished - 2003
EventMedical Imaging 2003: Image Perception, Observer Performance, and Technology Assessment - San Diego, CA, United States
Duration: Feb 18 2003Feb 20 2003

Other

OtherMedical Imaging 2003: Image Perception, Observer Performance, and Technology Assessment
CountryUnited States
CitySan Diego, CA
Period2/18/032/20/03

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Keywords

  • Grayscale window/level
  • Lesion detection
  • Mammography
  • Observer performance
  • Visual discrimination model

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Condensed Matter Physics

Cite this

Johnson, J. P., Nafziger, J., Krupinski, E. A., Lubin, J., & Roehrig, H. (2003). Effects of grayscale window/level parameters on breast lesion detectability. In P. Chakraborty, & E. A. Krupinski (Eds.), Proceedings of SPIE - The International Society for Optical Engineering (Vol. 5034, pp. 462-473) https://doi.org/10.1117/12.480340