Effects of halothane and fentanyl anesthesia on plasma β-endorphin immunoreactivity during cardiac surgery

R. C. Cork, S. R. Hameroff, J. L. Weiss

Research output: Contribution to journalArticle

10 Scopus citations


We studied the effects of halothane anesthesia (n = 6) and fentanyl anesthesia (n = 9; 50-100 μg/kg) on plasma β-endorphin immunoreactivity as a measure of stress response during coronary artery bypass grafting, including cardiopulmonary bypass. Plasma levels of β-endorphin immunoreactivity measured prior to induction, after induction, after intubation, after skin incision, during cardiopulmonary bypass, and on leaving the operating room were significantly higher in patients given halothane during cardiopulmonary bypass and on leaving the operating room than they were in patients given fentanyl.

Original languageEnglish (US)
Pages (from-to)677-680
Number of pages4
JournalAnesthesia and analgesia
Issue number7
StatePublished - Jan 1 1985


ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Cite this