Effects of intravenous and aerosolized arachidonic acid on alveolar epithelial permeability in rabbits

J. L. Stevenson, S. F. Quan, M. L. Witten, J. N. Hall, H. R. Roseberry, G. C. McNeill, R. J. Lemen

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

To determine whether arachidonic acid (AA) alters alveolar epithelial permeability, we studied the effect of both continuous intravenous and aerosolized AA on clearance of [99m]Tc-DTPA from lung to blood in rabbits. Although intravenous AA increased prostacylin production and aerosolized AA decreased systemic blood pressure, neither continuous intravenous nor aerosolized AA augmented alveolar epithelial permeability.

Original languageEnglish (US)
Pages (from-to)113-116
Number of pages4
JournalResearch Communications in Chemical Pathology and Pharmacology
Volume72
Issue number1
StatePublished - Apr 29 1991

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Toxicology
  • Pharmacology
  • Pharmacology, Toxicology and Pharmaceutics(all)

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    Stevenson, J. L., Quan, S. F., Witten, M. L., Hall, J. N., Roseberry, H. R., McNeill, G. C., & Lemen, R. J. (1991). Effects of intravenous and aerosolized arachidonic acid on alveolar epithelial permeability in rabbits. Research Communications in Chemical Pathology and Pharmacology, 72(1), 113-116.