Effects of N-allylnormetazocine (skf 10,047), phencyclidine, and other psychomotor stimulants in the rat following 6-hydroxydopamine lesion of the ventral tegmental area

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Abstract

The depletion of mesolimbic dopamine by 6-hydroxydopamine injections into the a10 region of the ventral tegmental area effectively blocked locomotor hyperactivity induced by SKF 10,047, phencyclidine and amphetamine, whereas the stimulatory effects of caffeine and scopolamine were not altered by the lesion. These results suggest that SKF 10,047, like amphetamine, and phencyclidine acts through presynaptic dopaminergic mechanisms in the mesolimbic nucleus accumbens system to stimulate locomotor behavior.

Original languageEnglish (US)
Pages (from-to)447-450
Number of pages4
JournalNeuropharmacology
Volume25
Issue number4
DOIs
StatePublished - 1986
Externally publishedYes

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Phencyclidine
Ventral Tegmental Area
Oxidopamine
Amphetamine
Scopolamine Hydrobromide
Nucleus Accumbens
Caffeine
Dopamine
Injections
SK&F 10047

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Drug Discovery
  • Pharmacology

Cite this

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abstract = "The depletion of mesolimbic dopamine by 6-hydroxydopamine injections into the a10 region of the ventral tegmental area effectively blocked locomotor hyperactivity induced by SKF 10,047, phencyclidine and amphetamine, whereas the stimulatory effects of caffeine and scopolamine were not altered by the lesion. These results suggest that SKF 10,047, like amphetamine, and phencyclidine acts through presynaptic dopaminergic mechanisms in the mesolimbic nucleus accumbens system to stimulate locomotor behavior.",
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AB - The depletion of mesolimbic dopamine by 6-hydroxydopamine injections into the a10 region of the ventral tegmental area effectively blocked locomotor hyperactivity induced by SKF 10,047, phencyclidine and amphetamine, whereas the stimulatory effects of caffeine and scopolamine were not altered by the lesion. These results suggest that SKF 10,047, like amphetamine, and phencyclidine acts through presynaptic dopaminergic mechanisms in the mesolimbic nucleus accumbens system to stimulate locomotor behavior.

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