Effects of neuroleptics on different types of catatonia in rats with hereditary predisposition to catatonic reactions

V. G. Kolpakov, E. M. Nikulina, T. A. Alekhina, M. M. Gevorgyan

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Rats of GC strain with genetic predisposition to cataleptic reactions bred from Wistar rats are more sensitive to cataleptogenic effect of haloperidol and trifluperidol than Wistar rats. At the sane time, chlorpromazine and sulpiride considerably shorten the time of maintenance of imposed vertical cataleptic postures for which GC strain has been selected. This paradoxical situation is interpreted so that the more pronounced neuroleptic-induced catalepsy in GC rats is caused by increased sensitivity of postsynaptic dopamine D receptors in the striatum, while the predisposition to the cataleptic postures attenuated by neuroleptics is associated with dopaminergic hyperactivity of the mesolimbic system.

Original languageEnglish (US)
Pages (from-to)388-394
Number of pages7
JournalZhurnal Vysshei Nervnoi Deyatelnosti Imeni I.P. Pavlova
Volume45
Issue number2
StatePublished - Jan 1 1995
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)

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