Effects of normal pregnancy on cellular cation metabolism and peripheral vascular resistance

J. R. Sowers, M. B. Zemel, M. F. Walsh, Paul R Standley, P. C. Zemel, R. A. Bronsteen, J. Kraniak, R. J. Sokol

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Normal pregnancy is associated with a poorly understood loss of vascular responsiveness to the pressor effects of infused angiotensin II. Since cellular cation metabolism appears to be a critical determinant of basal vascular tone and vascular reactivity, we have evaluated platelet ionized calcium, erythrocyte sodium, calcium and magnesium levels, and erythrocyte Ca-ATPase and Na/K ATPase activity in 15 normal black pregnant women (37.5 ± 0.6 weeks gestation) and 10 normal age-matched nonpregnant black women. Plasma levels of factors potentially affecting vascular reactivity (endoxin, renin activity (PRA), and atrial natriuretic peptide (ANP)) were measured by RIA and peripheral vascular resistance by biolectrical impedance. Peripheral vascular resistance was almost twice as high (P < .003) in the normal group as in the pregnant women. Intracellular calcium concentrations were not significantly different in erythrocytes or platelets of the two groups. Although erythrocyte membrane Ca-ATPase was similar, Na/K ATPase activity was significantly higher in the pregnant subjects than in the nonpregnant controls, and intracellular sodium was lower. All three measured plasma factors, ANP, endoxin and PRA, were significantly elevated in the pregnant women. Our results suggest that the decrease in peripheral vascular resistance seen in normal pregancy is probably not the result of alterations in cellular cation concentrations and/or cell membrane pump activity. However, the significant correlation between vascular reactivity and circulating ANP indicates this potent vasodilator may play a role in the observed decrease in peripheral vascular resistance associated with pregnancy.

Original languageEnglish (US)
Pages (from-to)16-22
Number of pages7
JournalAmerican Journal of Hypertension
Volume3
Issue number1
StatePublished - 1990
Externally publishedYes

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Vascular Resistance
Cations
Pregnancy
Blood Vessels
Atrial Natriuretic Factor
Pregnant Women
Erythrocytes
Calcium
Blood Platelets
Sodium
Erythrocyte Membrane
Electric Impedance
Vasodilator Agents
Renin
Angiotensin II
Magnesium
Adenosine Triphosphatases
Cell Membrane

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Sowers, J. R., Zemel, M. B., Walsh, M. F., Standley, P. R., Zemel, P. C., Bronsteen, R. A., ... Sokol, R. J. (1990). Effects of normal pregnancy on cellular cation metabolism and peripheral vascular resistance. American Journal of Hypertension, 3(1), 16-22.

Effects of normal pregnancy on cellular cation metabolism and peripheral vascular resistance. / Sowers, J. R.; Zemel, M. B.; Walsh, M. F.; Standley, Paul R; Zemel, P. C.; Bronsteen, R. A.; Kraniak, J.; Sokol, R. J.

In: American Journal of Hypertension, Vol. 3, No. 1, 1990, p. 16-22.

Research output: Contribution to journalArticle

Sowers, JR, Zemel, MB, Walsh, MF, Standley, PR, Zemel, PC, Bronsteen, RA, Kraniak, J & Sokol, RJ 1990, 'Effects of normal pregnancy on cellular cation metabolism and peripheral vascular resistance', American Journal of Hypertension, vol. 3, no. 1, pp. 16-22.
Sowers, J. R. ; Zemel, M. B. ; Walsh, M. F. ; Standley, Paul R ; Zemel, P. C. ; Bronsteen, R. A. ; Kraniak, J. ; Sokol, R. J. / Effects of normal pregnancy on cellular cation metabolism and peripheral vascular resistance. In: American Journal of Hypertension. 1990 ; Vol. 3, No. 1. pp. 16-22.
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