Effects of oxygen deprivation on incubated rat soleus muscle

Julie M. Fagan, Marc E. Tischler

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Isolated soleus muscle deprived of oxygen produces more lactate and alanine than oxygen-supplied muscle. Oxygenated muscle synthesized glutamine, while anoxic muscle used this amino acid. Oxygen deprivation decreased adenine nucleotides leading to the efflux of nucleosides. Protein synthesis and degradation responded differently to anoxia. Synthesis almost completely ceased, while proteolysis increased. Therefore, protein degradation in soleus muscle is enhanced when energy supplies and oxygen tension are low.

Original languageEnglish (US)
Pages (from-to)677-681
Number of pages5
JournalLife Sciences
Volume44
Issue number10
DOIs
StatePublished - 1989
Externally publishedYes

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ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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