Effects of parental smoking on interferon γ production in children

Gina Tebow, Duane L Sherrill, I. Carla Lohman, Debra A. Stern, Anne L Wright, Fernando Martinez, Marilyn Halonen, Stefano Guerra

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Environmental tobacco smoke is associated with several negative health outcomes in children, including an increased susceptibility to infections. One of the postulated mechanisms for these effects is the impairment of the immune system function and/or development. Yet, it remains unknown whether cumulative exposure to parental smoking is associated with altered immune responses in childhood and whether these effects are independent of in utero exposure to maternal smoking. In a population-based birth cohort, we sought to determine the relation of parental smoking, as assessed prospectively since pregnancy, to the child's interferon γ and interleukin 4 production at 11 years of age. Patients and methods. We used data on 512 children and their parents from the tucson children's respiratory study cohort. Information on maternal and paternal smoking was collected prospectively by questionnaire, and pack-years for mother, father, and both parents combined were assessed prospectively between the prenatal period and year 11. At age 11 years, children's interferon γ and interleukin 4 production from mitogen-stimulated peripheral blood mononuclear cells was measured. Results. Children of parents who smoked between the prenatal period and year 11 were more likely to be in lower quartiles of interferon γ production than children of nonsmoking parents. In addition, maternal, paternal, and parental pack-years showed significant inverse dose-response relationships with interferon γ production in the child. These dose-response relationships with interferon γ remained significant for both paternal and parental pack-years among children of mothers who did not smoke during pregnancy, suggesting the existence of specific postnatal effects of environmental tobacco smoke exposure. In contrast, no significant effects of parental smoking were found on interleukin 4 production. Conclusions. Interferon γ responses of school-aged children are impacted by parental smoking.

Original languageEnglish (US)
JournalPediatrics
Volume121
Issue number6
DOIs
StatePublished - Jun 2008

Fingerprint

Interferons
Smoking
Parents
Mothers
Smoke
Interleukin-4
Tobacco
Maternal Exposure
Pregnancy
Mitogens
Fathers
Immune System
Blood Cells
Cohort Studies
Parturition
Health
Infection

Keywords

  • Environmental tobacco smoke
  • ETS
  • IFN-γ
  • Interferon γ
  • Interleukin 4, iL-4 objectives.
  • Smoking

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Effects of parental smoking on interferon γ production in children. / Tebow, Gina; Sherrill, Duane L; Lohman, I. Carla; Stern, Debra A.; Wright, Anne L; Martinez, Fernando; Halonen, Marilyn; Guerra, Stefano.

In: Pediatrics, Vol. 121, No. 6, 06.2008.

Research output: Contribution to journalArticle

Tebow, Gina ; Sherrill, Duane L ; Lohman, I. Carla ; Stern, Debra A. ; Wright, Anne L ; Martinez, Fernando ; Halonen, Marilyn ; Guerra, Stefano. / Effects of parental smoking on interferon γ production in children. In: Pediatrics. 2008 ; Vol. 121, No. 6.
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