Effects of recombinant bovine somatotropin (rbST) and season on plasma and milk insulin-like growth factors I (IGF-I) and II (IGF-II) in lactating dairy cows

Robert J Collier, M. A. Miller, C. L. McLaughlin, H. D. Johnson, C. A. Baile

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

During two studies, effects of recombinant bovine somatotropin (rbST) on plasma and milk IGF's in cows adapted to summer (S; 12 cows) or winter (W; 12 cows) conditions were evaluated. Each study consisted of on-farm periods (30 days) followed by climatology chamber periods (CC; 30 days). Cows were given daily injections of rbST, Sometribove, USAN (25 mg/day; 6 cows each study) or saline (control; 6 cows each study). During on-farm periods, blood and milk (am and pm) samples were collected once weekly. During CC periods, blood samples were collected every 2 days and milk samples (am and pm) were collected daily. Plasma IGF-I and IGF-II were increased in cows treated with rbST. A pronounced seasonal pattern in basal and rbST-stimulated plasma IGF-I but not IGF-II was detected. Higher basal and rbST-stimulated plasma IGF-I concentrations in S occurred despite large decreases in feed intake and energy balance. Milk IGF-I and IGF-II was not affected by rbST treatment or season. Although milk IGF-I and IGF-II concentrations were unaffected by rbST treatment, total IGF-output increased due to increased milk yield. The observed seasonal patterns in plasma IGF-I may be indicative of seasonal differences in the coupling of the somatotropin-IGF axis. In particular, we failed to detect an uncoupling of the somatotropin-IGF-I axis in S despite an induced negative energy balance during thermal stress.

Original languageEnglish (US)
Pages (from-to)16-23
Number of pages8
JournalDomestic Animal Endocrinology
Volume35
Issue number1
DOIs
StatePublished - Jul 2008

Fingerprint

insulin-like growth factor II
Insulin-Like Growth Factor II
insulin-like growth factor I
Insulin-Like Growth Factor I
Transforming Growth Factor beta
somatotropin
Growth Hormone
dairy cows
milk
cows
Milk
energy balance
bovine growth hormone
seasonal variation
Meteorology
farms
thermal stress
blood
Energy Intake
sampling

Keywords

  • Cattle
  • IGF-I
  • IGF-II
  • rbST
  • Season

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)
  • Endocrinology

Cite this

Effects of recombinant bovine somatotropin (rbST) and season on plasma and milk insulin-like growth factors I (IGF-I) and II (IGF-II) in lactating dairy cows. / Collier, Robert J; Miller, M. A.; McLaughlin, C. L.; Johnson, H. D.; Baile, C. A.

In: Domestic Animal Endocrinology, Vol. 35, No. 1, 07.2008, p. 16-23.

Research output: Contribution to journalArticle

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