Effects of Retinoids on Human Lymphocyte Functions in vitro

S. Moriguchi, J. C. Jacksont, R. R. Watson

Research output: Contribution to journalArticle

41 Scopus citations

Abstract

1 E-Rosette formation in vitro, lymphocyte mitogenesis and natural killer (NK) activity of human blood lymphocytes were strongly inhibited by high concentration (10-4 M) of retinol or retinal. Other retinoids at 10-4 M (retinoic acid and 13-cis-retinoic acid) and lower concentrations (10-7 or 10-9 M) of retinol, retinal and carotenes also inhibited E-rosette formation. 2 Lymphocyte transformation responses induced by concanavalin A (Con A) or pokeweed mitogen (PWM) were also inhibited while NK activity was not affected. 3 There was a remarkable depression of the total number of viable lymphocytes after incubation with retinol or retinal 10-4 M. However, other retinoids, 10-7 and 10-9 M of retinol and retinal and carotenes did not show marked decrease of lymphocyte number or viability even after prolonged incubation (48 h). 4 The mechanism of inhibition by retinol or retinal (10-4 M) is due in part to the decrease of viable lymphocytes. It is unclear how other retinoids, carotenes and lower concentrations (10-7 or 10-9 M) of retinol or retinal inhibit E-rosette formation or lymphocyte transformation.

Original languageEnglish (US)
Pages (from-to)365-378
Number of pages14
JournalHuman & Experimental Toxicology
Volume4
Issue number4
DOIs
StatePublished - Jul 1985

ASJC Scopus subject areas

  • Toxicology
  • Health, Toxicology and Mutagenesis

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