Effects of selective modulation of the central melanocortin-3-receptor on food intake and hypothalamic POMC expression

Michelle Lee, Andrea Kim, Irene M. Conwell, Victor Hruby, Alexander Mayorov, Minying Cai, Sharon L. Wardlaw

Research output: Contribution to journalArticlepeer-review

38 Scopus citations

Abstract

Hypothalamic POMC neurons regulate energy balance via interactions with brain melanocortin receptors (MC-Rs). POMC neurons express the MC3-R which can function as an inhibitory autoreceptor in vitro. We now demonstrate that central activation of MC3-R with ICV infusion of the specific MC3-R agonist, [d-Trp8]-γ-MSH, transiently suppresses hypothalamic Pomc expression and stimulates food intake in rats. Conversely, we also show that ICV infusion of a low dose of a selective MC3-R antagonist causes a transient decrease in feeding and weight gain. These data support a functional inhibitory role for the MC3-R on POMC neurons that leads to changes in food intake.

Original languageEnglish (US)
Pages (from-to)440-447
Number of pages8
JournalPeptides
Volume29
Issue number3
DOIs
StatePublished - Mar 2008

Keywords

  • Feeding
  • MSH
  • Melanocortin-3-receptor
  • POMC

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Endocrinology
  • Cellular and Molecular Neuroscience

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