Effects of selenium and vitamin E deficiencies on reproduction, growth, blood components, and tissue lesions in sheep fed purified diets

P. D. Whanger, P. H. Weswig, J. A. Schmitz, J. E. Oldfield

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Three 2 x 2 factorial experiments were conducted with sheep fed purified diets to determine the effects of selenium and vitamin E on the incidence of white muscle disease (WMD) and blood components. All lambs reaching 6 wk of age in the group receiving no vitamin E or selenium developed WMD lesions, whereas only a few lambs in either the +E -Se or -E +Se treatment groups developed these lesions. Plasma activities of creatine phosphokinase, lactic dehydrogenase and glutamic oxaloacetic transaminase were significantly elevated in lambs receiving no vitamin E or selenium, whereas these enzyme activities in those receiving only selenium were non-significantly elevated. The enzyme activities in plasma of those on the +E -Se or +E +Se treatments were maintained at low levels, suggesting vitamin E alone is more effective in preventing WMD than selenium alone. The metabolic interactions of these essentials are discussed.

Original languageEnglish (US)
Pages (from-to)1288-1297
Number of pages10
JournalJournal of Nutrition
Issue number7
StatePublished - Dec 1 1977


ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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