Effects of selenium in vitro on human T-lymphocyte functions and K-562 tumor cell growth

Ronald R Watson, S. Moriguchi, B. McRae, L. Tobin, J. C. Mayberry, D. Lucas

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Abstract

In vitro E-rosette formation, lymphocyte mitogenesis, and natural killer (NK) cell activity of human blood lymphocytes were strongly inhibited by high concentrations (10-4 M) of sodium selenite, sodium selenate, and selenium dioxide. Lower concentrations (10-5 or 10-7 M) also inhibited E-rosette formation and natural killer cell activity against K-562 tumor cells. Lymphocyte transformation induced by concanavalin A (con A) or pokeweed mitogen (PWM) was also inhibited by all selenium compounds tested, but only at the highest concentrations (10-5 and 10-4 M). There was depression of the total number of viable lymphocytes following incubation with selenium dioxide only at a high concentration (10-4 M). Interferon production was enhanced at lower levels (10-9 to 10-6 M) of selenium dioxide while a higher concentration (10-5 and 10-4 M) appeared to inhibit its production. The mechanism of inhibition by selenium compounds (10-4 M) is due, in part, to the decrease of viable lymphocytes. It is unclear how other and lower concentrations (10-7 or 10-9 M) of selenium compounds inhibit E-rosette formation, NK activity, or K-562 tumor cell growth.

Original languageEnglish (US)
Pages (from-to)447-456
Number of pages10
JournalJournal of Leukocyte Biology
Volume39
Issue number4
StatePublished - 1986

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Selenium Oxides
Selenium Compounds
Rosette Formation
Selenium
Lymphocytes
T-Lymphocytes
Natural Killer Cells
Growth
Selenic Acid
Sodium Selenite
Pokeweed Mitogens
Neoplasms
Lymphocyte Count
Lymphocyte Activation
Concanavalin A
Human Activities
Interferons
In Vitro Techniques

ASJC Scopus subject areas

  • Cell Biology

Cite this

Watson, R. R., Moriguchi, S., McRae, B., Tobin, L., Mayberry, J. C., & Lucas, D. (1986). Effects of selenium in vitro on human T-lymphocyte functions and K-562 tumor cell growth. Journal of Leukocyte Biology, 39(4), 447-456.

Effects of selenium in vitro on human T-lymphocyte functions and K-562 tumor cell growth. / Watson, Ronald R; Moriguchi, S.; McRae, B.; Tobin, L.; Mayberry, J. C.; Lucas, D.

In: Journal of Leukocyte Biology, Vol. 39, No. 4, 1986, p. 447-456.

Research output: Contribution to journalArticle

Watson, RR, Moriguchi, S, McRae, B, Tobin, L, Mayberry, JC & Lucas, D 1986, 'Effects of selenium in vitro on human T-lymphocyte functions and K-562 tumor cell growth', Journal of Leukocyte Biology, vol. 39, no. 4, pp. 447-456.
Watson, Ronald R ; Moriguchi, S. ; McRae, B. ; Tobin, L. ; Mayberry, J. C. ; Lucas, D. / Effects of selenium in vitro on human T-lymphocyte functions and K-562 tumor cell growth. In: Journal of Leukocyte Biology. 1986 ; Vol. 39, No. 4. pp. 447-456.
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