Effects of self-reported age at nonsurgical menopause on time to first fracture and bone mineral density in the Women's Health Initiative Observational Study

Shannon D. Sullivan, Amy Lehman, Fridtjof Thomas, Karen C. Johnson, Rebecca Jackson, Jean Wactawski-Wende, Marcia Ko, Zhao Chen, J. David Curb, Barbara V. Howard

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Objective: Menopause is a risk factor for fracture; thus, menopause age may affect bone mass and fracture rates. We compared bone mineral density (BMD) and fracture rates among healthy postmenopausal women with varying ages at self-reported nonsurgical menopause. Methods: We compared hazard ratios for fractures and differences in BMD among 21,711 postmenopausal women from the Women's Health Initiative Observational Study cohort who had no prior hysterectomy, oophorectomy, or hormone therapy and had varying self-reported ages at menopause (2; 95% CI, -0.07 to -0.004; P=0.03) and women who reported menopause at age 50 years or older (estimated difference, -0.05 g/cm2; 95% CI, -0.08 to -0.02; P2; 95% CI, -0.08 to -0.01; P=0.01), and total spine BMD was lower in women who underwent menopause before age 40 years than in women who underwent menopause at age 50 years or older (estimated difference, -0.11 g/cm2; 95% CI, -0.16 to -0.06; P2; 95% CI, -0.15 to -0.04; P

Original languageEnglish (US)
Pages (from-to)1035-1044
Number of pages10
JournalMenopause
Volume22
Issue number10
DOIs
StatePublished - Oct 1 2015

Keywords

  • Bone mineral density
  • Fracture
  • Menopause
  • Premature menopause

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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    Sullivan, S. D., Lehman, A., Thomas, F., Johnson, K. C., Jackson, R., Wactawski-Wende, J., Ko, M., Chen, Z., Curb, J. D., & Howard, B. V. (2015). Effects of self-reported age at nonsurgical menopause on time to first fracture and bone mineral density in the Women's Health Initiative Observational Study. Menopause, 22(10), 1035-1044. https://doi.org/10.1097/GME.0000000000000451