Effects of sepsis on neonatal thrombopoiesis

Rachel E. Brown, Lisa M Rimsza, Karen Pastos, Linda Young, Matthew A. Saxonhouse, Matthew Bailey, Robert M. Lawrence, Martha C. Sola-Visner

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

We serially evaluated the effects of sepsis and/or necrotizing enterocolitis (NEC) on neonatal thrombopoiesis, using a panel of tests that included platelet counts, thrombopoietin concentrations (Tpo), circulating megakaryocyte progenitor concentrations (CMPs), and reticulated platelets (RPs). Variables analyzed included sepsis type, time after onset of sepsis, platelet counts, and gestational (GA) and postconceptional ages (PCA). Twenty neonates were enrolled. Ten had Gram-negative, six had Gram-positive, and four had presumed sepsis. Four neonates had NEC stage II or higher, and six developed thrombocytopenia. Overall, septic neonates had significantly elevated Tpo concentrations and circulating megakaryocyte progenitors. The highest Tpo levels were associated with Gram-negative or presumed sepsis. RP percentages were increased only in neonates with low platelet counts, while RP counts (RP% x platelet count) were elevated in neonates with high platelet counts. Our findings suggest that septic neonates up-regulate Tpo production, leading to increased megakaryocytopoiesis and platelet release, although the degree of upregulation is moderate. The changes in RP% and RP count most likely reflect increased thrombopoiesis with variable degrees of platelet consumption. In addition, our findings suggest that different factors, likely including level of illness and/or specific platelet or bacterial products, can down-regulate the magnitude of the thrombopoietic response.

Original languageEnglish (US)
Pages (from-to)399-404
Number of pages6
JournalPediatric Research
Volume64
Issue number4
DOIs
StatePublished - Oct 2008

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Thrombopoiesis
Platelet Count
Blood Platelets
Thrombopoietin
Sepsis
Megakaryocyte Progenitor Cells
Necrotizing Enterocolitis
Up-Regulation
Cytidine Monophosphate
Neonatal Sepsis
Thrombocytopenia
Gestational Age
Down-Regulation

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Brown, R. E., Rimsza, L. M., Pastos, K., Young, L., Saxonhouse, M. A., Bailey, M., ... Sola-Visner, M. C. (2008). Effects of sepsis on neonatal thrombopoiesis. Pediatric Research, 64(4), 399-404. https://doi.org/10.1203/PDR.0b013e318181ad49

Effects of sepsis on neonatal thrombopoiesis. / Brown, Rachel E.; Rimsza, Lisa M; Pastos, Karen; Young, Linda; Saxonhouse, Matthew A.; Bailey, Matthew; Lawrence, Robert M.; Sola-Visner, Martha C.

In: Pediatric Research, Vol. 64, No. 4, 10.2008, p. 399-404.

Research output: Contribution to journalArticle

Brown, RE, Rimsza, LM, Pastos, K, Young, L, Saxonhouse, MA, Bailey, M, Lawrence, RM & Sola-Visner, MC 2008, 'Effects of sepsis on neonatal thrombopoiesis', Pediatric Research, vol. 64, no. 4, pp. 399-404. https://doi.org/10.1203/PDR.0b013e318181ad49
Brown RE, Rimsza LM, Pastos K, Young L, Saxonhouse MA, Bailey M et al. Effects of sepsis on neonatal thrombopoiesis. Pediatric Research. 2008 Oct;64(4):399-404. https://doi.org/10.1203/PDR.0b013e318181ad49
Brown, Rachel E. ; Rimsza, Lisa M ; Pastos, Karen ; Young, Linda ; Saxonhouse, Matthew A. ; Bailey, Matthew ; Lawrence, Robert M. ; Sola-Visner, Martha C. / Effects of sepsis on neonatal thrombopoiesis. In: Pediatric Research. 2008 ; Vol. 64, No. 4. pp. 399-404.
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