Effects of single large doses of phenytoin on glucose homeostasis - a preliminary report

W. Banner, David G Johnson, P. D. Walson, D. Jung

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The effects of a loading dose of 15 mg/kg phenytoin by iv infusion on the serum levels of insulin, glucagon, and glucose were investigated in five fasting healthy male volunteers between the ages of 23 and 35 years. Serum glucose concentrations rose immediately after the infusion of phenytoin followed by a significant increase in serum insulin values (P <0.05). A slight elevation in mean glucagon concentrations after the infusion was not statistically significant. Further studies are indicated to determine whether phenytoin as used in the treatment of status epilepticus may aggravate the hyperglycemia associated with seizures.

Original languageEnglish (US)
Pages (from-to)79-81
Number of pages3
JournalJournal of Clinical Pharmacology
Volume22
Issue number2-3
StatePublished - 1982

Fingerprint

Phenytoin
Homeostasis
Glucagon
Glucose
Serum
Insulin
Status Epilepticus
Hyperglycemia
Fasting
Healthy Volunteers
Seizures
Therapeutics

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Effects of single large doses of phenytoin on glucose homeostasis - a preliminary report. / Banner, W.; Johnson, David G; Walson, P. D.; Jung, D.

In: Journal of Clinical Pharmacology, Vol. 22, No. 2-3, 1982, p. 79-81.

Research output: Contribution to journalArticle

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