Effects of the polyamine analogs BE-3-7-3, 3-8-3, and BE-3-8-3 on human brain tumor cell growth and survival

H. S. Basu, M. Pellarin, B. G. Feuerstein, D. F. Deen, L. J. Marton

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Based on computer modeling, physicochemical studies of spermine-DNA interactions, and cell culture experiments, we hypothesized that polyamine analogs with hydrocarbon chain lengths differing from natural polyamines and a stronger affinity for nucleic acids than spermine should have a cellular antiproliferative effect. We tested three spermine analogs with long hydrocarbon chains, 1,16-diamino-4,12-diazahexadecane (3-8-3), 1,16-bis(ethyl)amino-4,12-diazahexadecane (BE-3-8-3), and 1,15-bis(ethyl)amino-4,11-diazapentadecane (BE-3-7-3) in human brain tumor cell lines U-251 MG, SF-126, and SF-188. Analog concentrations ≤ 5 μM inhibited growth and colony-forming efficiency in each cell line by treatment day 5, with significant decreases in putrescine and spermidine, but not spermine, levels. These findings suggest that potentially cytotoxic polyamine analogs can be specified on the basis of their hydrocarbon chain length and DNA affinity.

Original languageEnglish (US)
Pages (from-to)1525-1532
Number of pages8
JournalAnticancer research
Volume13
Issue number5 A
StatePublished - Jan 1 1993
Externally publishedYes

Keywords

  • Cell growth
  • Cell survival
  • Human brain tumor cell lines
  • Intracellular polyamines
  • Polyamine analogs

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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