Effects of thyroid state on venous complicance and left ventricular performance in rats

R. G. Gay, T. E. Raya, L. D. Lancaster, R. W. Lee, E. Morkin, Steven Goldman

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Abstract

The cardiovascular system of hypothyroid, normal and hyperthyroid rats was studied by evaluation of the peripheral venous circulation and left ventricular (LV) systolic and diastolic performance in rats. Cardiac index (CI) and CI during a volume load were measured in open-chest rats. When compared with control, hypothyroid rats showed a decrease in heart rate, aortic pressure, LV systolic pressure, first derivative for LV pressure (LV dP/dt), CI, and CI during a volume load. LV pressure-volume relation was shifted to the right, muscle stiffness was unchanged, and LV relaxation was prolonged. There was a decrease in mean circulatory filling pressure (MCFP) to 6.3 ± 0.2 from 7.6 ± 0.2 mmHg in control rats. This was associated with an 11% decrease in unstressed vascular volume and 12% decrease in total blood volume but no change in venous compliance. In hyperthyroid rats there was an increase in heart rate, LV systolic pressure, LV dP/dt, CI, and CI during a volume load. LV chamber stiffness was increased, but muscle stiffness and LV relaxation were unchanged. There was an increase in MCFP to 9.5 ± 0.3 mmHg and a decrease in venous compliance to 2.65 ± 0.12 compared with 3.20 ± 0.09 ml·mmHg-1·kg-1 in control rats. Unstressed vascular volume and total blood volume were unchanged. In conclusion, hyperthyroid rats have augmented LV systolic function and altered diastolic function which, combined with changes in the venous circulation, result in increased venous return and thus cardiac output. In hypothyroid rats both LV systolic and diastolic function are altered. When combined with changes of the venous circulation the changes result in a decrease in cardiac output.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume254
Issue number1
StatePublished - 1988
Externally publishedYes

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Thyroid Gland
Ventricular Pressure
Hyperthyroidism
Blood Volume
Cardiac Output
Blood Vessels
Heart Rate
Blood Pressure
Pressure
Muscles
Cardiovascular System
Left Ventricular Function
Compliance
Arterial Pressure
Thorax

ASJC Scopus subject areas

  • Physiology

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Effects of thyroid state on venous complicance and left ventricular performance in rats. / Gay, R. G.; Raya, T. E.; Lancaster, L. D.; Lee, R. W.; Morkin, E.; Goldman, Steven.

In: American Journal of Physiology - Heart and Circulatory Physiology, Vol. 254, No. 1, 1988.

Research output: Contribution to journalArticle

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AU - Morkin, E.

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